Δημοσίευση

Effects of albumin/glutaraldehyde glue on healing of colonic anastomosis in rats.

ΤίτλοςEffects of albumin/glutaraldehyde glue on healing of colonic anastomosis in rats.
Publication TypeJournal Article
Year of Publication2017
AuthorsDespoudi, K., Mantzoros I., Ioannidis O., Cheva A., Antoniou N., Konstantaras D., Symeonidis S., Pramateftakis M. George, Kotidis E., Angelopoulos S., & Tsalis K.
JournalWorld J Gastroenterol
Volume23
Issue31
Pagination5680-5691
Date Published2017 Aug 21
ISSN2219-2840
Λέξεις κλειδιάAdhesives, Anastomosis, Surgical, Anastomotic Leak, Animals, Collagenases, Colon, Humans, Hydroxyproline, Incidence, Male, Models, Animal, Proteins, Rats, Rats, Wistar, Surgical Wound Dehiscence, Tissue Adhesives, Wound Healing
Abstract

AIM: To evaluate the effect of local surgical adhesive glue (albumin/glutaraldehyde-Bioglue) on the healing of colonic anastomoses in rats.METHODS: Forty Albino-Wistar male rats were randomly divided into two groups, with two subgroups of ten animals each. In the control group, an end-to-end colonic anastomosis was performed after segmental resection. In the Bioglue group, the anastomosis was protected with extraluminar application of adhesive glue containing albumin and glutaraldehyde. Half of the rats were sacrificed on the fourth and the rest on the eighth postoperative day. Anastomoses were resected and macroscopically examined. Bursting pressures were calculated and histological features were graded. Other parameters of healing, such as hydroxyproline and collagenase concentrations, were evaluated. The experimental data were summarized and computed from the results of a one-way ANOVA. Fisher's exact test was applied to compare percentages.RESULTS: Bursting pressures, adhesion formation, inflammatory cell infiltration, and collagen deposition were significantly higher on the fourth postoperative day in the albumin/glutaraldehyde group than in the control group. Furthermore, albumin/glutaraldehyde significantly increased adhesion formation, inflammatory cell infiltration, neoangiogenesis, and collagen deposition on the eighth postoperative day. There was no difference in fibroblast activity or hydroxyproline and collagenase concentrations.CONCLUSION: Albumin/glutaraldehyde, when applied on colonic anastomoses, promotes their healing in rats. Therefore, the application of protective local agents in colonic anastomoses leads to better outcomes.

DOI10.3748/wjg.v23.i31.5680
Alternate JournalWorld J. Gastroenterol.
PubMed ID28883693
PubMed Central IDPMC5569282

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