The effects of iloprost on colonic anastomotic healing in rats.
Τίτλος | The effects of iloprost on colonic anastomotic healing in rats. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Galanopoulos, G., Pramateftakis M. G., Raptis D., Mantzoros I., Kanellos D., Angelopoulos S., Koliakos G., Zaraboukas T., & Lazaridis C. |
Journal | Tech Coloproctol |
Volume | 15 Suppl 1 |
Pagination | S117-20 |
Date Published | 2011 Oct |
ISSN | 1128-045X |
Λέξεις κλειδιά | Anastomosis, Surgical, Animals, Collagenases, Colon, Hydroxyproline, Iloprost, Male, Neovascularization, Physiologic, Pressure, Rats, Rats, Wistar, Rupture, Time Factors, Tissue Adhesions, Vasodilator Agents, Wound Healing |
Abstract | PURPOSE: The purpose of this experimental study is to investigate the effects of iloprost on colonic anastomotic healing in rats, after intraperitoneal administration.METHODS: Forty male Albino-Wistar rats were randomized into two groups of twenty animals each. They all underwent colonic resection followed by an inverted anastomosis. The rats of Group A (control) received 3 ml of NaCl intraperitoneally, while those of Group B (iloprost) received iloprost (2 μg/kg body weight), immediately postoperatively and daily until killed. Each group was further divided into two equal subgroups, depending on the day of killing. The animals of subgroups 1 were killed on the fourth postoperative day, while those of subgroups 2 on the eighth. Macroscopical and histological assessments were performed. Besides, anastomotic bursting pressures and the tissue concentrations in hydroxyproline and collagenase I were also evaluated.RESULTS: No anastomotic dehiscence was noted. The mean bursting pressure was higher in the iloprost group compared with the control group, but a significant difference was revealed only on the fourth postoperative day. Furthermore, iloprost significantly increased the new vessel formation on the fourth, as well as on the eighth postoperative day.CONCLUSION: Iloprost enhances the early phase of colonic anastomotic healing in rats. |
DOI | 10.1007/s10151-011-0758-5 |
Alternate Journal | Tech Coloproctol |
PubMed ID | 21956403 |