Elevated levels of MMP-9 in untreated patients with stage I essential hypertension.
| Τίτλος | Elevated levels of MMP-9 in untreated patients with stage I essential hypertension. |
| Publication Type | Journal Article |
| Year of Publication | 2012 |
| Authors | Gkaliagkousi, E., Doumas M., Gavriilaki E., Triantafyllou A., Vogiatzis K., Anyfanti P., Petidis K., & Douma S. |
| Journal | Clin Exp Hypertens |
| Volume | 34 |
| Issue | 8 |
| Pagination | 561-6 |
| Date Published | 2012 |
| ISSN | 1525-6006 |
| Λέξεις κλειδιά | Adult, Algorithms, Biomarkers, Case-Control Studies, Female, Humans, Hypertension, Interleukin-6, Male, Matrix Metalloproteinase 2, Matrix Metalloproteinase 9, Middle Aged, Predictive Value of Tests, Protease Inhibitors, Risk Factors, Sensitivity and Specificity, Severity of Illness Index, Tissue Inhibitor of Metalloproteinase-1, Tissue Inhibitor of Metalloproteinase-2, Tumor Necrosis Factor-alpha |
| Abstract | Increased expression and activity of metalloproteinases have been implicated in the pathophysiology of vascular remodeling and in the growth of atherosclerotic lesions. We aimed at determining the levels of MMP-2, MMP-9, their specific inhibitors TIMP-2 and TIMP-1, and the inflammatory cytokines IL-6 and TNF-α, which are related to the stimulation of MMPs, in patients with untreated mild essential hypertension (UH) and normotensive (NT) volunteers. Serum MMP-9 and TIMP-1 levels were significantly different in UH volunteers when compared to NT volunteers. Thus, MMP-9 is elevated in the early stages of essential hypertension and may be used as a marker of cardiovascular risk and vascular dysfunction. |
| DOI | 10.3109/10641963.2012.681726 |
| Alternate Journal | Clin Exp Hypertens |
| PubMed ID | 22574960 |
