Elevated serum levels of interleukin-6, interleukin-1β and human chorionic gonadotropin in pre-eclampsia.
Τίτλος | Elevated serum levels of interleukin-6, interleukin-1β and human chorionic gonadotropin in pre-eclampsia. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Kalinderis, M., Papanikolaou A., Kalinderi K., Ioannidou E., Giannoulis C., Karagiannis V., & Tarlatzis B. C. |
Journal | Am J Reprod Immunol |
Volume | 66 |
Issue | 6 |
Pagination | 468-75 |
Date Published | 2011 Dec |
ISSN | 1600-0897 |
Λέξεις κλειδιά | Adult, Case-Control Studies, Chorionic Gonadotropin, Female, Humans, Interleukin-1beta, Interleukin-6, Pre-Eclampsia, Pregnancy, Pregnancy Complications, Pregnancy Trimester, Third, Prospective Studies, Up-Regulation |
Abstract | PROBLEM: Pre-eclampsia (PE) is a pregnancy-specific syndrome of unknown aetiology. It is believed to involve an inflammatory process. The aim of the study was to investigate and compare the concentrations of two proinflammatory cytokines interleukin-6 (IL-6) and interleukin-1β (IL-1β) and to evaluate the possible interaction between them and human chorionic gonadotropin (hCG) in women with normotensive pregnancy and PE.METHOD OF STUDY: A prospective case-control study was carried out in 30 women with PE and 30 normotensive controls. Serum IL-1β, IL-6 and hCG levels were determined by enzyme-linked immunosorbent assay (ELISA) and automated immunofluorescent assay, respectively.RESULTS: Serum IL-6, IL-1β and hCG levels were significantly increased in women with PE compared to controls (P < 0.001 for each); however, no correlation was found between IL-6, IL-1β and hCG.CONCLUSION: Our results highlight the inflammatory origin of PE and reinforce the possible role of hCG in the complex aetiology of its pathogenesis. |
DOI | 10.1111/j.1600-0897.2011.01019.x |
Alternate Journal | Am. J. Reprod. Immunol. |
PubMed ID | 21623995 |