Evaluation of the Insulin-like Growth Factor Receptor Pathway in Patients with Advanced Breast Cancer Treated with Trastuzumab.
Τίτλος | Evaluation of the Insulin-like Growth Factor Receptor Pathway in Patients with Advanced Breast Cancer Treated with Trastuzumab. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Christodoulou, C., Oikonomopoulos G., Koliou G. Angeliki, Kostopoulos I., Kotoula V., Bobos M., Pentheroudakis G., Lazaridis G., Skondra M., Chrisafi S., Koutras A., Bafaloukos D., Razis E., Papadopoulou K., Papakostas P., Kalofonos H. P., Pectasides D., Skarlos P., Kalogeras K. T., & Fountzilas G. |
Journal | Cancer Genomics Proteomics |
Volume | 15 |
Issue | 6 |
Pagination | 461-471 |
Date Published | 2018 Nov-Dec |
ISSN | 1790-6245 |
Λέξεις κλειδιά | Adult, Aged, Aged, 80 and over, Breast Neoplasms, Disease-Free Survival, Female, Gene Expression Regulation, Humans, Middle Aged, Neoplasm Metastasis, Neoplasm Proteins, Receptor, IGF Type 1, Retrospective Studies, Signal Transduction, Survival Rate, Trastuzumab |
Abstract | BACKGROUND: Trastuzumab is a monoclonal antibody against HER2-positive breast cancer. Despite improving the natural history of the disease, there is a number of patients who are resistant to it, whereas all patients will eventually develop resistance and disease will progress. Inconsistent preclinical data show that the IGF-R pathway may contribute to either de novo or acquired resistance to trastuzumab. |
DOI | 10.21873/cgp.20105 |
Alternate Journal | Cancer Genomics Proteomics |
PubMed ID | 30343280 |
PubMed Central ID | PMC6299784 |