Δημοσίευση

Fixed versus flexible gonadotropin-releasing hormone antagonist administration in in vitro fertilization: a randomized controlled trial.

ΤίτλοςFixed versus flexible gonadotropin-releasing hormone antagonist administration in in vitro fertilization: a randomized controlled trial.
Publication TypeJournal Article
Year of Publication2011
AuthorsKolibianakis, E. M., Venetis C. A., Kalogeropoulou L., Papanikolaou E., & Tarlatzis B. C.
JournalFertil Steril
Volume95
Issue2
Pagination558-62
Date Published2011 Feb
ISSN1556-5653
Λέξεις κλειδιάAdult, Dose-Response Relationship, Drug, Female, Fertility Agents, Female, Fertilization in Vitro, Gonadotropin-Releasing Hormone, Hormone Antagonists, Humans, Infertility, Luteinizing Hormone, Ovulation Induction, Pregnancy, Pregnancy Rate
Abstract

OBJECTIVE: To evaluate whether the incidence of luteinizing hormone (LH) rise is reduced by using a flexible compared with a fixed day-6 protocol of GnRH antagonist administration.DESIGN: Randomized controlled trial.SETTING: Tertiary university hospital.PATIENT(S): Patients undergoing in vitro fertilization (n = 146).INTERVENTION(S): Ovarian stimulation was performed using recombinant FSH and GnRH antagonists. GnRH antagonist cetrorelix (0.25 mg/d) was started either on day 6 of stimulation (fixed group) or when LH was >10 IU/L, and/or a follicle with mean diameter >12 mm was present, and/or serum E(2) was >150 pg/mL. Patient monitoring was initiated on day 3 of stimulation.MAIN OUTCOME MEASURE(S): Incidence of LH rise.RESULT(S): No statistically significant difference was observed between the flexible and fixed groups regarding the incidence of LH rise, which was lower in the flexible group (11.0% vs. 15.1%, difference -4.1%, 95% confidence interval -15.4% to +7.1%). No LH surges were observed in any of the patients studied.CONCLUSION(S): Flexible antagonist administration from day 3 onward does not appear to reduce the incidence of LH rises compared with fixed antagonist administration on day 6 of stimulation.

DOI10.1016/j.fertnstert.2010.05.052
Alternate JournalFertil. Steril.
PubMed ID20637457

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