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Genetic databases in pharmacogenomics: the Frequency of Inherited Disorders Database (FINDbase).

ΤίτλοςGenetic databases in pharmacogenomics: the Frequency of Inherited Disorders Database (FINDbase).
Publication TypeJournal Article
Year of Publication2013
AuthorsGeorgitsi, M., & Patrinos G. P.
JournalMethods Mol Biol
Volume1015
Pagination321-36
Date Published2013
ISSN1940-6029
Λέξεις κλειδιάDatabases, Genetic, Gene Frequency, Humans, Pharmacogenetics, Polymorphism, Genetic, Polymorphism, Single Nucleotide
Abstract

Pharmacogenomics studies how the variations of the individuals' genetic makeup are correlated with a person's response to certain drugs in relation to the therapeutic efficiency, clinical outcome, or even survival, and how they affect drug metabolism, transport, or clearance. Yet, since the incidence of these polymorphisms, being either single-point variations or small insertions/deletions, varies among different populations, a systematic collection and documentation of these variations is warranted, in order to facilitate implementation of pharmacogenomics in different populations. Here we review the existing electronic databases related to pharmacogenomics and pay particular attention in the description of the pharmacogenomics module Frequency of Inherited Disorders database (FINDbase), which documents curated allelic frequency data pertaining to 144 pharmacogenomics markers across 14 genes, representing approximately 87,000 individuals from 150 populations and ethnic groups worldwide. Long-term sustainability of these resources aims to contribute to the design, development, and implementation of pharmacogenomics testing towards the application of personalized approaches in medical treatment.

DOI10.1007/978-1-62703-435-7_21
Alternate JournalMethods Mol. Biol.
PubMed ID23824866

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