Glutathion-S-Transferase P1 polymorphisms association with broncopulmonary dysplasia in preterm infants.
Τίτλος | Glutathion-S-Transferase P1 polymorphisms association with broncopulmonary dysplasia in preterm infants. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Karagianni, P., Rallis D., Fidani L., Porpodi M., Kalinderi K., Tsakalidis C., & Nikolaidis N. |
Journal | Hippokratia |
Volume | 17 |
Issue | 4 |
Pagination | 363-7 |
Date Published | 2013 Oct |
ISSN | 1108-4189 |
Abstract | BACKGROUND: Oxidative stress, characterized by the excretion of pre-oxidative and anti-oxidative proteases, has a key role in the pathogenesis of bronchopulmonary dysplasia (BPD). One of the many host anti-oxidant enzymes is glutathione-S-transferase P1 (GSTP1), with three polymorphic alleles having been identified: homozygous ile, heterozygous ile/val and homozygous val isomorph. The aim of this study was to examine the genetic predisposition to BPD in the GSTP1 polymorphisms.METHODS: A prospective case-control study was carried out in the 2nd Neonatal Intensive Care Unit of Aristotle University in Thessaloniki, Greece during 2008. The genetic polymorphisms of GSTP1 in 28 preterms <32 weeks gestational age (GA) with BPD compared to 74 controls (33 preterms without BPD and 41 healthy terms) were examined.RESULTS: The homozygous ile isomorph was predominant in all groups (preterms with BPD: 82%, preterms without BPD: 70%, healthy terms: 78%), followed by the heterozygous ile/val (14%, 18% and 20% respectively) and the homozygous val isomorph (4%, 12% and 2% respectively). The homozygous ile isomorph was also identified in the majority of preterms with mild (80%), moderate (100%) and severe (73%) BPD. The GSTP1 genetic distribution did not differ between the groups and GSTP1 polymorphisms were not associated with the severity of BPD.CONCLUSIONS: This study could not confirm an association between GSTP1 polymorphisms and the development of BPD or the severity of the disease. |
Alternate Journal | Hippokratia |
PubMed ID | 25031518 |
PubMed Central ID | PMC4097420 |