HCC influence on patient survival after liver transplantation for HDV cirrhosis.
Τίτλος | HCC influence on patient survival after liver transplantation for HDV cirrhosis. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Imvrios, G., Vrochides D., Papanikolaou V., Fouzas I., Antoniadis N., Giakoustidis D., Ntinas A., Kardassis D., Akriviadis E., Vasiliadis T., Goulis I., Katsika E., Moutsianos G., Patsiaoura K., Tsoulfas G., & Takoudas D. |
Journal | Hepatogastroenterology |
Volume | 58 |
Issue | 110-111 |
Pagination | 1654-8 |
Date Published | 2011 Sep-Oct |
ISSN | 0172-6390 |
Λέξεις κλειδιά | Adolescent, Adult, Carcinoma, Hepatocellular, Chi-Square Distribution, Disease-Free Survival, Female, Follow-Up Studies, Hepatitis B, Hepatitis D, Humans, Liver Cirrhosis, Liver Neoplasms, Liver Transplantation, Male, Middle Aged, Retrospective Studies, Statistics, Nonparametric, Survival Rate, Treatment Outcome |
Abstract | BACKGROUND/AIMS: The effect of hepatocellular cancer (HCC) in patients transplanted for hepatitis B and D virus (HB/DV) cirrhosis is not well studied. Our aim was to study the long-term survival outcomes of patients who underwent liver transplantation for HB/DV cirrhosis with and without HCC.METHODOLOGY: A total of 231 primary, adult, single- organ liver transplants were performed from 1990 to 2007. HB/DV was the cause of cirrhosis in 36 patients. Nine patients died during the first 3 postoperative months from surgical complications. The study group comprised the remaining 27 patients. The median follow-up was 1515 days.RESULTS: The mean patient survival was 3760 days (95% CI: 3013-4507). Six patients were diagnosed with HCC. The mean patient survival was 3011 days (95% CI: 2344-3679) and 4036 days (95% CI: 3002-5070) for recipients without and with HCC, respectively. For the same groups, the incidence of microbial infections was 61.9% and 33.3%, respectively (p=0.219). HCC has not recurred in any of the six patients.CONCLUSIONS: The mean long-term survival after liver transplantation for HB/DV and HCC surpassed 11 years. The superior survival of HCC patients is difficult to explain. The increased number (almost double) of microbial infections in the non- HCC population might be held accountable. |
DOI | 10.5754/hge10096 |
Alternate Journal | Hepatogastroenterology |
PubMed ID | 22086696 |