Δημοσίευση

HCC influence on patient survival after liver transplantation for HDV cirrhosis.

ΤίτλοςHCC influence on patient survival after liver transplantation for HDV cirrhosis.
Publication TypeJournal Article
Year of Publication2011
AuthorsImvrios, G., Vrochides D., Papanikolaou V., Fouzas I., Antoniadis N., Giakoustidis D., Ntinas A., Kardassis D., Akriviadis E., Vasiliadis T., Goulis I., Katsika E., Moutsianos G., Patsiaoura K., Tsoulfas G., & Takoudas D.
JournalHepatogastroenterology
Volume58
Issue110-111
Pagination1654-8
Date Published2011 Sep-Oct
ISSN0172-6390
Λέξεις κλειδιάAdolescent, Adult, Carcinoma, Hepatocellular, Chi-Square Distribution, Disease-Free Survival, Female, Follow-Up Studies, Hepatitis B, Hepatitis D, Humans, Liver Cirrhosis, Liver Neoplasms, Liver Transplantation, Male, Middle Aged, Retrospective Studies, Statistics, Nonparametric, Survival Rate, Treatment Outcome
Abstract

BACKGROUND/AIMS: The effect of hepatocellular cancer (HCC) in patients transplanted for hepatitis B and D virus (HB/DV) cirrhosis is not well studied. Our aim was to study the long-term survival outcomes of patients who underwent liver transplantation for HB/DV cirrhosis with and without HCC.METHODOLOGY: A total of 231 primary, adult, single- organ liver transplants were performed from 1990 to 2007. HB/DV was the cause of cirrhosis in 36 patients. Nine patients died during the first 3 postoperative months from surgical complications. The study group comprised the remaining 27 patients. The median follow-up was 1515 days.RESULTS: The mean patient survival was 3760 days (95% CI: 3013-4507). Six patients were diagnosed with HCC. The mean patient survival was 3011 days (95% CI: 2344-3679) and 4036 days (95% CI: 3002-5070) for recipients without and with HCC, respectively. For the same groups, the incidence of microbial infections was 61.9% and 33.3%, respectively (p=0.219). HCC has not recurred in any of the six patients.CONCLUSIONS: The mean long-term survival after liver transplantation for HB/DV and HCC surpassed 11 years. The superior survival of HCC patients is difficult to explain. The increased number (almost double) of microbial infections in the non- HCC population might be held accountable.

DOI10.5754/hge10096
Alternate JournalHepatogastroenterology
PubMed ID22086696

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