Δημοσίευση

HER-2/neu is an independent prognostic factor in type I endometrial adenocarcinoma.

ΤίτλοςHER-2/neu is an independent prognostic factor in type I endometrial adenocarcinoma.
Publication TypeJournal Article
Year of Publication2014
AuthorsKalogiannidis, I., Petousis S., Bobos M., Margioula-Siarkou C., Topalidou M., Papanikolaou A., Vergote I., & Agorastos T.
JournalArch Gynecol Obstet
Volume290
Issue6
Pagination1231-7
Date Published2014 Dec
ISSN1432-0711
Λέξεις κλειδιάAdenocarcinoma, Carcinoma, Endometrioid, Disease-Free Survival, Endometrial Neoplasms, Female, Follow-Up Studies, Greece, Humans, Multivariate Analysis, Neoplasm Grading, Neoplasm Staging, Prognosis, Proportional Hazards Models, PTEN Phosphohydrolase, Receptor, ErbB-2, Survival Rate, Tissue Array Analysis, Treatment Outcome
Abstract

PURPOSE: To define the prognostic significance of HER-2/neu and PTEN expression in patients with endometrioid (type I) endometrial cancer.METHODS: Seventy-seven patients with endometrioid endometrial carcinoma were included in the study, in a period between 1996 and 2009. Patients with coexisting malignancy and those having incomplete immunohistochemical data or clinical follow-up were excluded. Histological staging was defined according to the revised FIGO staging (2009). Clinico-pathologic and immunohistochemical characteristics were correlated in a multivariate Cox regression analysis with overall survival (OS), cancer-related survival (CRS) and disease-free survival (DFS).RESULTS: Mean age of the patients was 62.7 years. The median follow-up was 67 months (9-124 months). HER-2/neu expression was detected in 18.2 % (n = 14), and PTEN expression in 72.7 % (n = 56) of our patients. Multivariate Cox regression analysis showed that patient's age, FIGO staging and HER-2/neu expression were independent prognostic factors for OS, CRS and DFS. PTEN expression did not significantly affect survival outcomes of the present study.CONCLUSIONS: HER-2/neu but not PTEN expression is an independent prognostic factor for type I endometrial carcinoma.

DOI10.1007/s00404-014-3333-2
Alternate JournalArch. Gynecol. Obstet.
PubMed ID25022554

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