The hypothalamic-pituitary-adrenal axis in women with differentiated thyroid cancer.
| Τίτλος | The hypothalamic-pituitary-adrenal axis in women with differentiated thyroid cancer. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Chrisoulidou, A., Pazaitou-Panayiotou K., Georgiou E., Boudina M., Lytras K., Iakovou I., Vainas I., & Kaltsas G. |
| Journal | Endocr Res |
| Volume | 35 |
| Issue | 3 |
| Pagination | 137-43 |
| Date Published | 2010 |
| ISSN | 1532-4206 |
| Λέξεις κλειδιά | Adenocarcinoma, Follicular, Adrenocorticotropic Hormone, Adult, Blood Glucose, Carcinoma, Carcinoma, Papillary, Cardiovascular Diseases, Circadian Rhythm, Corticotropin-Releasing Hormone, Dexamethasone, Female, Glucose Tolerance Test, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Insulin, Insulin Resistance, Lipids, Middle Aged, Pituitary-Adrenal System, Thyroid Cancer, Papillary, Thyroid Neoplasms |
| Abstract | INTRODUCTION: We studied the function of hypothalamic-pituitary-adrenal (HPA) axis in females with differentiated thyroid cancer (DTC) and its sequelae on metabolism and cardiovascular risk.METHODS AND RESULTS: Sixteen women were investigated with (1) morning, evening, and midnight cortisol and adrenocortophic hormone, (2) cortisol after overnight 1 mg dexamethasone suppression test, (3) cortisol after corticotropin releasing hormone test, (4) oral glucose tolerance test with glucose and insulin estimations, and (5) ultrasound for carotid intima media thickness. A matched control group underwent similar investigations. None of the parameters was significantly different between patients and controls.CONCLUSION: Females with DTC have normal HPA-axis function and similar insulin sensitivity and cardiovascular risk compared to controls. |
| DOI | 10.3109/07435800.2010.496760 |
| Alternate Journal | Endocr Res |
| PubMed ID | 20712436 |
