Δημοσίευση

Immunohistochemical distinction between merkel cell carcinoma and small cell carcinoma of the lung.

ΤίτλοςImmunohistochemical distinction between merkel cell carcinoma and small cell carcinoma of the lung.
Publication TypeJournal Article
Year of Publication2006
AuthorsBobos, M., Hytiroglou P., Kostopoulos I., Karkavelas G., & Papadimitriou C. S.
JournalAm J Dermatopathol
Volume28
Issue2
Pagination99-104
Date Published2006 Apr
ISSN0193-1091
Λέξεις κλειδιάAdult, Aged, Aged, 80 and over, Biomarkers, Tumor, Carcinoma, Merkel Cell, Carcinoma, Small Cell, CD56 Antigen, Chromogranins, Female, Humans, Immunohistochemistry, Keratin-20, Keratin-7, Keratins, Lung Neoplasms, Male, Middle Aged, Neurofilament Proteins, Nuclear Proteins, Phosphopyruvate Hydratase, Proto-Oncogene Proteins c-kit, Receptor, ErbB-2, S100 Proteins, Skin Neoplasms, Synaptophysin, Thyroid Gland, Thyroid Nuclear Factor 1, Transcription Factors, Vimentin
Abstract

We assessed the usefulness of several immunohistochemical stains in distinguishing these two neoplasms, including cytokeratin 7, cytokeratin 20 (CK20), neuron-specific enolase, chromogranin, synaptophysin, neurofilaments (NF), thyroid-transcription factor-1 (TTF-1), CD56 antigen, S-100 protein, vimentin, c-erbB-2 oncoprotein, and CD117 antigen. All 13 cases of Merkel cell carcinoma evaluated were positive for CK20, and negative for TTF-1. Twelve of 13 Merkel cell carcinoma cases were positive for NF. Eleven of 13 cases of small cell lung carcinoma were positive for TTF-1. All small cell lung carcinoma cases were negative for NF, and all but one were negative for CK20. In terms of the remaining antigens, there were no differences of significance between the two neoplasms. These findings suggest that a set of three immunohistochemical stains, including CK20, NF, and TTF-1, is useful in affording a distinction between Merkel cell carcinoma and small cell lung carcinoma.

DOI10.1097/01.dad.0000183701.67366.c7
Alternate JournalAm J Dermatopathol
PubMed ID16625069

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