Δημοσίευση

Investigation of cytokine levels and their association with SCORAD index in adults with acute atopic dermatitis.

ΤίτλοςInvestigation of cytokine levels and their association with SCORAD index in adults with acute atopic dermatitis.
Publication TypeJournal Article
Year of Publication2011
AuthorsVakirlis, E., Lazaridou E., Tzellos T. G., Gerou S., Chatzidimitriou D., & Ioannides D.
JournalJ Eur Acad Dermatol Venereol
Volume25
Issue4
Pagination409-16
Date Published2011 Apr
ISSN1468-3083
Λέξεις κλειδιάAdolescent, Adult, Case-Control Studies, Child, Child, Preschool, Cytokines, Dermatitis, Atopic, Female, Flow Cytometry, Humans, Immunoglobulin E, Infant, Infant, Newborn, Male, Severity of Illness Index, Tumor Necrosis Factor-alpha
Abstract

BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disease with increasing frequency over the last decades, especially in adults. Cytokines orchestrate atopic skin inflammation. Objectives  The aim of this study was to compare serum levels of cytokines in adult patients with acute AD (AD1) with other groups of AD patients and controls and investigate the possible association between such cytokines and disease severity.METHODS: We measured cytokine levels using flow cytometry in 21 adult patients with acute AD, 12 adults with chronic AD, 10 children with acute AD and 10 healthy adults.RESULTS: Flow cytometry analysis of cytokines revealed that interleukin 10 (IL-10), IL-6, interferon γ (IFN-γ) and IL-4 levels were significantly decreased in AD1 group compared with controls, whereas IL-2 and tumour necrosis factor (TNF) did not differ. Comparison of AD1 group with adults chronic phase group showed that IgE, eosinophil and IL-2 levels remained unaltered, whereas IL-10, IL-6, IFN-γ, IL-4 and TNF were significantly decreased. SCORAD and IgE levels were significantly increased, IL-10, IL-6 and IFN-γ were decreased and TNF, IL-2, IL-4 and eosinophil levels remained unchanged in AD1 group compared with children acute phase group. Within AD1 group correlation analysis revealed that IgE and TNF levels were significantly associated with AD severity. Coefficient of determination analysis revealed that TNF and IgE levels could explain 49.14% and 35.28% of the variance of SCORAD.CONCLUSIONS: These data indicate that serum IgE and TNF levels correlate with AD severity and that serum cytokines are downregulated in AD1 group. Further studies are clearly needed to elucidate cytokines' role in adults with AD.

DOI10.1111/j.1468-3083.2010.03800.x
Alternate JournalJ Eur Acad Dermatol Venereol
PubMed ID21371129

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