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Knowledge engineering for adverse drug event prevention: on the design and development of a uniform, contextualized and sustainable knowledge-based framework.

ΤίτλοςKnowledge engineering for adverse drug event prevention: on the design and development of a uniform, contextualized and sustainable knowledge-based framework.
Publication TypeJournal Article
Year of Publication2012
AuthorsKoutkias, V., Kilintzis V., Stalidis G., Lazou K., Nies J., Durand-Texte L., McNair P., Beuscart R., & Maglaveras N.
JournalJ Biomed Inform
Volume45
Issue3
Pagination495-506
Date Published2012 Jun
ISSN1532-0480
Λέξεις κλειδιάDecision Support Systems, Clinical, Drug-Related Side Effects and Adverse Reactions, Humans, Knowledge Bases
Abstract

The primary aim of this work was the development of a uniform, contextualized and sustainable knowledge-based framework to support adverse drug event (ADE) prevention via Clinical Decision Support Systems (CDSSs). In this regard, the employed methodology involved first the systematic analysis and formalization of the knowledge sources elaborated in the scope of this work, through which an application-specific knowledge model has been defined. The entire framework architecture has been then specified and implemented by adopting Computer Interpretable Guidelines (CIGs) as the knowledge engineering formalism for its construction. The framework integrates diverse and dynamic knowledge sources in the form of rule-based ADE signals, all under a uniform Knowledge Base (KB) structure, according to the defined knowledge model. Equally important, it employs the means to contextualize the encapsulated knowledge, in order to provide appropriate support considering the specific local environment (hospital, medical department, language, etc.), as well as the mechanisms for knowledge querying, inference, sharing, and management. In this paper, we present thoroughly the establishment of the proposed knowledge framework by presenting the employed methodology and the results obtained as regards implementation, performance and validation aspects that highlight its applicability and virtue in medication safety.

DOI10.1016/j.jbi.2012.01.007
Alternate JournalJ Biomed Inform
PubMed ID22326287

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