Major Adipokines and the -420C>G Resistin Gene Polymorphism as Predictors of Acute Ischemic Stroke Severity and In-Hospital Outcome.
Τίτλος | Major Adipokines and the -420C>G Resistin Gene Polymorphism as Predictors of Acute Ischemic Stroke Severity and In-Hospital Outcome. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Bouziana, S. D., Tziomalos K., Goulas A., Vyzantiadis T-A., Panderi A., & Ηatzitolios A. Ι. |
Journal | J Stroke Cerebrovasc Dis |
Volume | 27 |
Issue | 4 |
Pagination | 963-970 |
Date Published | 2018 Apr |
ISSN | 1532-8511 |
Λέξεις κλειδιά | Adiponectin, Aged, Aged, 80 and over, Brain Ischemia, Chi-Square Distribution, Disability Evaluation, Female, Gene Frequency, Genetic Predisposition to Disease, Hospital Mortality, Hospitalization, Humans, Leptin, Logistic Models, Male, Odds Ratio, Phenotype, Polymorphism, Genetic, Promoter Regions, Genetic, Prospective Studies, Recovery of Function, Resistin, Risk Factors, Severity of Illness Index, Stroke, Time Factors, Treatment Outcome |
Abstract | BACKGROUND: The role of adiponectin, leptin, and resistin and the -420C>G polymorphism of the resistin gene promoter in the pathogenesis of ischemic stroke are controversial. We aimed to evaluate whether serum levels of these adipokines and the -420C>G polymorphism are associated with ischemic stroke severity and in-hospital outcome.METHODS: We prospectively studied 93 patients who were consecutively hospitalized for acute ischemic stroke (39.8% males, age 79.7 ± 6.3 years). Stroke severity was evaluated at admission by the National Institutes of Health Stroke Scale (NIHSS). In-hospital outcome was evaluated by dependency rates at discharge and in-hospital mortality.RESULTS: The G allele was more prevalent in patients with severe stroke (P < .05). Independent predictors of severe stroke were high-sensitivity C-reactive protein levels (relative risk [RR] 1.43, 95% confidence interval [CI] 1.08-1.91, P < .05). Patients with dependency at discharge had lower serum leptin levels (P < .05). Independent predictors of functional dependence were prior ischemic stroke (RR 7.55, 95% CI 1.69-33.58, P < .01), serum triglyceride levels (RR .98, 95% CI .96-0.99, P < .05), and NIHSS at admission (RR 1.47, 95% CI 1.17-1.84, P < .001). The G allele was more prevalent in patients who died (P < .05). Independent predictors of in-hospital mortality were systolic blood pressure (RR 1.09, 95% CI 1.01-1.19, P < .05) and NIHSS at admission (RR 1.26, 95% CI 1.08-1.48, P < .005).CONCLUSIONS: The G allele of the -420C>G polymorphism of the resistin gene promoter appears to be associated with more severe stroke and higher in-hospital mortality in patients with acute ischemic stroke. Higher leptin levels appear to be related to favorable functional outcome. |
DOI | 10.1016/j.jstrokecerebrovasdis.2017.10.038 |
Alternate Journal | J Stroke Cerebrovasc Dis |
PubMed ID | 29217361 |