Mannose binding lectin and ficolin-2 polymorphisms are associated with increased risk for bacterial infections in children with B acute lymphoblastic leukemia.
Τίτλος | Mannose binding lectin and ficolin-2 polymorphisms are associated with increased risk for bacterial infections in children with B acute lymphoblastic leukemia. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Pana, Z. Dorothea, Samarah F., Papi R., Antachopoulos C., Papageorgiou T., Farmaki E., Hatzipantelis E., Tragiannidis A., Vavatsi-Christaki N., Kyriakidis D., Athanassiadou-Piperopoulou F., & Roilides E. |
Journal | Pediatr Blood Cancer |
Volume | 61 |
Issue | 6 |
Pagination | 1017-22 |
Date Published | 2014 Jun |
ISSN | 1545-5017 |
Λέξεις κλειδιά | Adolescent, Antineoplastic Combined Chemotherapy Protocols, Bacterial Infections, Child, Child, Preschool, Codon, Exons, Febrile Neutropenia, Female, Genetic Predisposition to Disease, Genotype, Haplotypes, Humans, Immunity, Innate, Immunocompromised Host, Infant, Lectins, Male, Mannose-Binding Lectin, Metabolism, Inborn Errors, Polymorphism, Genetic, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Risk |
Abstract | BACKGROUND: We aimed to investigate whether the presence of mannose binding lectin (MBL2), ficolin 2 (FCN2) polymorphisms or the combined deficiency significantly influence the risk and subsequently the frequency of chemotherapy-induced bacterial infections in children with B acute lymphoblastic leukemia (B-ALL).PROCEDURE: MBL2 polymorphisms for exon 1 and FCN2 polymorphisms for promoter regions -986, -602, -557, -64, -4 and exon 8 regions +6,359, +6,424 were determined in children with B-ALL. FCN2 haplotype was determined by gene sequencing. Number and duration of FN episodes as well as number of bacterial infections were recorded during induction chemotherapy.RESULTS: Forty-four children with B-ALL (median age 4.3 years, 65.9% males) suffered from 142 FN episodes and 92 bacterial infections (40.2% Gram positive and 59.8% Gram negative). MBL2 low-risk genotype was found in 59.1%, medium-risk in 31.8% and high-risk in 9%. FCN2 low-risk haplotypes were detected in 38.2%, medium-risk in 44.1% and high-risk in 17.6%. MBL2 genotype and FCN2 haplotype were not associated with increased frequency of FN episodes. MBL2 medium/high-risk genotype and FCN2 medium/high-risk haplotype were associated with prolonged duration of FN (P = 0.007 and P = 0.001, respectively) and increased number of bacterial infections (P = 0.001 and P = 0.002, respectively). The combined MBL2/FCN2 medium/high-risk genotype was associated with an increased number of bacterial infections (P = 0.001).CONCLUSIONS: MBL2 and FCN2 single or combined deficiencies are associated with increased duration of FN episodes as well as increased number of bacterial infections in children with B-ALL suggesting a prognostic role of these genes. |
DOI | 10.1002/pbc.24951 |
Alternate Journal | Pediatr Blood Cancer |
PubMed ID | 24453114 |