Δημοσίευση

The Marine Polysaccharide Ulvan Confers Potent Osteoinductive Capacity to PCL-Based Scaffolds for Bone Tissue Engineering Applications.

ΤίτλοςThe Marine Polysaccharide Ulvan Confers Potent Osteoinductive Capacity to PCL-Based Scaffolds for Bone Tissue Engineering Applications.
Publication TypeJournal Article
Year of Publication2021
AuthorsKikionis, S., Ioannou E., Aggelidou E., Tziveleka L-A., Demiri E., Bakopoulou A., Zinelis S., Kritis A., & Roussis V.
JournalInt J Mol Sci
Volume22
Issue6
Date Published2021 Mar 17
ISSN1422-0067
Λέξεις κλειδιάAquatic Organisms, Bone and Bones, Cell Adhesion, Elasticity, Gene Expression Regulation, Humans, Mesenchymal Stem Cells, Osteogenesis, Polyesters, Polysaccharides, Spectroscopy, Fourier Transform Infrared, Thermogravimetry, Tissue Engineering, Tissue Scaffolds, Water
Abstract

Hybrid composites of synthetic and natural polymers represent materials of choice for bone tissue engineering. Ulvan, a biologically active marine sulfated polysaccharide, is attracting great interest in the development of novel biomedical scaffolds due to recent reports on its osteoinductive properties. Herein, a series of hybrid polycaprolactone scaffolds containing ulvan either alone or in blends with κ-carrageenan and chondroitin sulfate was prepared and characterized. The impact of the preparation methodology and the polysaccharide composition on their morphology, as well as on their mechanical, thermal, water uptake and porosity properties was determined, while their osteoinductive potential was investigated through the evaluation of cell adhesion, viability, and osteogenic differentiation of seeded human adipose-derived mesenchymal stem cells. The results verified the osteoinductive ability of ulvan, showing that its incorporation into the polycaprolactone matrix efficiently promoted cell attachment and viability, thus confirming its potential in the development of biomedical scaffolds for bone tissue regeneration applications.

DOI10.3390/ijms22063086
Alternate JournalInt J Mol Sci
PubMed ID33802984
PubMed Central IDPMC8002638
Grant ListT1EDK-02499 / / General Secretariat for Research and Technology /

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