Masked and white coat hypertension, the double trouble of large arteries: A systematic review and meta-analysis.
Τίτλος | Masked and white coat hypertension, the double trouble of large arteries: A systematic review and meta-analysis. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Antza, C., Vazakidis P., Doundoulakis I., Bouras E., Haidich A-B., Stabouli S., & Kotsis V. |
Journal | J Clin Hypertens (Greenwich) |
Volume | 22 |
Issue | 5 |
Pagination | 802-811 |
Date Published | 2020 May |
ISSN | 1751-7176 |
Abstract | Arterial damage of large arteries, addressed as c-f PWV, is recognized as independent predictor for future cardiovascular disease. The aim of this study was to systematically investigate the association of the four hypertension phenotypes with carotid-femoral pulse wave velocity (c-f PWV), in untreated patients. PubMed and Cochrane Library were searched to identify studies comparing c-f PWV levels between normotensives, sustained hypertensives, white-coat hypertensives (WCH), and masked hypertensives (MH). Meta-analysis was performed to compare the difference c-f PWV levels between these groups. Newcastle-Ottawa quality assessment scale for cross-sectional studies was used to assess study quality. MH and WCH patients had significantly increased c-f PWV values compared to the normotensive groups (d = 0.96 m/s, 95% CI: 0.49-1.42; I2 = 85%, P < .01 for MH and d = 0.85 m/s, 95% CI: 0.48-1.22; I2 = 89%, for WCH). Moreover, the sustained hypertensive population was found to have significantly increased values of c-f PWV compared to MH (d = -0.70 m/s, 95% CI: -0.87 to -0.54; I2 = 12%, P = .33) but not compared to WCH population (d = -0.75 m/s, 95% CI: -1.52-0.02; I = 96%,). Finally, there was no significant difference between MH and WCH population (d = 0.06 m/s, 95% CI: -1.04 to 1.15; I = 96%,). MH and WCH population may have increased values of c-f PWV compared to the normotensive group. These results demonstrate that these phenotypes are not clinically innocent, in the untreated population. |
DOI | 10.1111/jch.13876 |
Alternate Journal | J Clin Hypertens (Greenwich) |
PubMed ID | 32356941 |