Methylenetetrahydrofolate reductase C677T polymorphism: association with risk for childhood acute lymphoblastic leukemia and response during the initial phase of chemotherapy in greek patients.
Τίτλος | Methylenetetrahydrofolate reductase C677T polymorphism: association with risk for childhood acute lymphoblastic leukemia and response during the initial phase of chemotherapy in greek patients. |
Publication Type | Journal Article |
Year of Publication | 2006 |
Authors | Chatzidakis, K., Goulas A., Athanassiadou-Piperopoulou F., Fidani L., Koliouskas D., & Mirtsou V. |
Journal | Pediatr Blood Cancer |
Volume | 47 |
Issue | 2 |
Pagination | 147-51 |
Date Published | 2006 Aug |
ISSN | 1545-5009 |
Λέξεις κλειδιά | Adolescent, Alanine Transaminase, Antineoplastic Combined Chemotherapy Protocols, Case-Control Studies, Child, Child, Preschool, Female, Gene Frequency, Genotype, Greece, Humans, Infant, Male, Methylenetetrahydrofolate Reductase (NADPH2), Polymorphism, Genetic, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Retrospective Studies |
Abstract | BACKGROUND: As of late, a number of studies have focused on the association of the gene for methyletetrahydrofolate reductase (MTHFR) with risk for acute lymphoblastic leukemia (ALL) in children and in adults, as well as with response to chemotherapy. The degree of this association may vary according to the ethnic background and geographic localization of the population under study, or the phase of treatment when response to chemotherapy is concerned. |
DOI | 10.1002/pbc.20574 |
Alternate Journal | Pediatr Blood Cancer |
PubMed ID | 16123993 |