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MitraClip device for patients with functional mitral valve regurgitation: A systematic review.

ΤίτλοςMitraClip device for patients with functional mitral valve regurgitation: A systematic review.
Publication TypeJournal Article
Year of Publication2019
AuthorsChatzistergiou, K. T., Papanastasiou C. A., Kokkinidis D. G., Ziakas A. G., Karvounis H. I., & Karamitsos T. D.
JournalHellenic J Cardiol
Volume60
Issue2
Pagination101-107
Date Published2019 Mar - Apr
ISSN2241-5955
Λέξεις κλειδιάAged, Aged, 80 and over, Atrial Fibrillation, Cardiac Catheterization, Coronary Artery Disease, Female, Heart Valve Prosthesis, Heart Valve Prosthesis Implantation, Humans, Hypertension, Male, Middle Aged, Mitral Valve Insufficiency, Mortality, Observational Studies as Topic, Prevalence, Randomized Controlled Trials as Topic, Treatment Outcome
Abstract

BACKGROUND: MitraClip device is a novel therapeutic option for patients with degenerative mitral valve regurgitation. Nevertheless, several studies have also focused on the safety and efficacy of this method in functional mitral valve regurgitation (FMR).AIM: To systematically review all original studies that provided mortality data among FMR patients treated with MitraClip.MATERIALS AND METHODS: We conducted an in-depth literature search of 3 electronic databases (Medline, Scopus and Cochrane Library) in order to identify studies investigating the efficacy of MitraClip in FMR. Thirty-day and 12-month mortality after MitraClip implantation were the measured outcomes.RESULTS: Twenty-eight studies, involving 2383 patients, were included. The phenotype of the studied population was characterized by clinical and echocardiographic parameters suggesting severe FMR (NYHA III-IV: 91%, MR≥3+: 98%) with high surgical risk (mean Euroscore: 24.6%). The Mitraclip device was successfully implanted in 95.8% of patients, resulting in a reduction of two or more degrees of MR. Thirty day and 12-month mortality rates were estimated to be 2.3% and 18.9%, respectively.CONCLUSIONS: MitraClip appears to be a safe therapeutic option for patients with FMR who are considered to be at high surgical risk.

DOI10.1016/j.hjc.2019.02.003
Alternate JournalHellenic J Cardiol
PubMed ID30853608

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