Multiplexed (18-Plex) Measurement of Signaling Targets and Cytotoxic T Cells in Trastuzumab-Treated Patients using Imaging Mass Cytometry.
Τίτλος | Multiplexed (18-Plex) Measurement of Signaling Targets and Cytotoxic T Cells in Trastuzumab-Treated Patients using Imaging Mass Cytometry. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Carvajal-Hausdorf, D. E., Patsenker J., Stanton K. P., Villarroel-Espindola F., Esch A., Montgomery R. R., Psyrri A., Kalogeras K. T., Kotoula V., Foutzilas G., Schalper K. A., Kluger Y., & Rimm D. L. |
Journal | Clin Cancer Res |
Volume | 25 |
Issue | 10 |
Pagination | 3054-3062 |
Date Published | 2019 05 15 |
ISSN | 1078-0432 |
Λέξεις κλειδιά | Adult, Antineoplastic Agents, Biomarkers, Tumor, Breast Neoplasms, Case-Control Studies, Cohort Studies, Female, Humans, Image Cytometry, Lymphocytes, Tumor-Infiltrating, Neoplasm Recurrence, Local, Signal Transduction, T-Lymphocytes, Cytotoxic, Trastuzumab |
Abstract | PURPOSE: Imaging mass cytometry (IMC) uses metal-conjugated antibodies to provide multidimensional, objective measurement of protein targets. We used this high-throughput platform to perform an 18-plex assessment of HER2 ICD/ECD, cytotoxic T-cell infiltration and other structural and signaling proteins in a cohort of patients treated with trastuzumab to discover associations with trastuzumab benefit. |
DOI | 10.1158/1078-0432.CCR-18-2599 |
Alternate Journal | Clin Cancer Res |
PubMed ID | 30796036 |
PubMed Central ID | PMC6522272 |
Grant List | R01 GM131642 / GM / NIGMS NIH HHS / United States UL1 TR001863 / TR / NCATS NIH HHS / United States R01 HG008383 / HG / NHGRI NIH HHS / United States R01 CA139431 / CA / NCI NIH HHS / United States P30 CA016359 / CA / NCI NIH HHS / United States |