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Neurological soft signs in familial and sporadic schizophrenia.

ΤίτλοςNeurological soft signs in familial and sporadic schizophrenia.
Publication TypeJournal Article
Year of Publication2019
AuthorsFountoulakis, K. N., Panagiotidis P., Kimiskidis V., Nimatoudis I., & Gonda X.
JournalPsychiatry Res
Volume272
Pagination222-229
Date Published2019 02
ISSN1872-7123
Λέξεις κλειδιάAdult, Comorbidity, Family, Female, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Nervous System Diseases, Psychotic Disorders, Schizophrenia, Young Adult
Abstract

OBJECTIVE: Neurological soft signs (NSS) are a group of minor non-localizable neurological abnormalities found more often in patients with schizophrenia. The aim of the current study was investigate whether there is any difference in their manifestation in familial vs. sporadic schizophrenia.MATERIAL AND METHODS: The study sample included 120 patients suffering from schizophrenia according to DSM-5 (71 males and 49 females; aged 32.79 ± 11.11 years old) and 110 normal controls (57 males and 53 females; aged 33.38 ± 10.14 years old). The assessment included the Neurological Evaluation Scale (NES) and the detailed investigation family history. The statistical analysis included exploratory Analysis of Covariance.RESULTS: The results of the current study suggest that NSS are more frequent in familial cases of schizophrenia and are even more pronounced in cases with family history of psychosis in either first or second degree relatives.DISCUSSION: Overall the results suggest the presence of a spectrum of increasing severity from healthy controls to sporadic cases, to cases with non-psychotic family history and eventually to cases with psychotic family history, rather than a categorical distribution.

DOI10.1016/j.psychres.2018.12.105
Alternate JournalPsychiatry Res
PubMed ID30590276

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