Neuropathology-driven Whole-genome Sequencing Study Points to Novel Candidate Genes for Healthy Brain Aging.
Τίτλος | Neuropathology-driven Whole-genome Sequencing Study Points to Novel Candidate Genes for Healthy Brain Aging. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Alexander, J., Ströbel T., Georgitsi M., Hönigschnabl S., Reiner A., Fischer P., Tsifintaris M., Paschou P., & Kovacs G. G. |
Journal | Alzheimer Dis Assoc Disord |
Volume | 33 |
Issue | 1 |
Pagination | 7-14 |
Date Published | 2019 Jan-Mar |
ISSN | 1546-4156 |
Λέξεις κλειδιά | Aged, 80 and over, Aging, Alzheimer Disease, Austria, Brain, Carrier Proteins, Female, Humans, Longitudinal Studies, Male, Nerve Tissue Proteins, Neuropathology, Whole Genome Sequencing |
Abstract | PURPOSE: Understanding the healthy brain aging process is key to uncover the mechanisms that lead to pathologic age-related neurodegeneration, including progression to Alzheimer disease (AD). We aimed to address the issue of pathologic heterogeneity that often underlies a clinical AD diagnosis. |
DOI | 10.1097/WAD.0000000000000294 |
Alternate Journal | Alzheimer Dis Assoc Disord |
PubMed ID | 30681437 |