OPG/RANK/RANKL signaling axis in patients with type I diabetes: Associations with parathormone and vitamin D.
Τίτλος | OPG/RANK/RANKL signaling axis in patients with type I diabetes: Associations with parathormone and vitamin D. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Karalazou, P., Ntelios D., Chatzopoulou F., Fragou A., Taousani M., Mouzaki K., Galli-Tsinopoulou A., Kouidou S., & Tzimagiorgis G. |
Journal | Ital J Pediatr |
Volume | 45 |
Issue | 1 |
Pagination | 161 |
Date Published | 2019 Dec 10 |
ISSN | 1824-7288 |
Λέξεις κλειδιά | Adolescent, Biomarkers, Case-Control Studies, Child, Child, Preschool, Diabetes Mellitus, Type 1, Disease Progression, Female, Humans, Male, Osteoprotegerin, Parathyroid Hormone, Prognosis, RANK Ligand, Receptor Activator of Nuclear Factor-kappa B, Reference Values, Vitamin D |
Abstract | BACKGROUND: Type 1 diabetes (T1D) has been associated with a higher fracture risk due to alterations in bone structure and metabolism. On the other hand, the important role of the RANKL/OPG/RANK signaling axis in bone physiology is well established. The aim of this study was to evaluate the levels of receptor activator of nuclear factor kappa-B ligand (RANKL), receptor activator of nuclear factor kappa-B (RANK) and plasma osteoprotegerin (OPG) levels, in T1D youngsters and to investigate factors that could influence the OPG/RANK/RANKL signaling axis such as 25-hydroxy vitamin D [25(OH) D], parathormone (PTH) and age. |
DOI | 10.1186/s13052-019-0748-1 |
Alternate Journal | Ital J Pediatr |
PubMed ID | 31823791 |
PubMed Central ID | PMC6902340 |