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Oxidative Stress and Acute Kidney Injury in Critical Illness: Pathophysiologic Mechanisms-Biomarkers-Interventions, and Future Perspectives.

ΤίτλοςOxidative Stress and Acute Kidney Injury in Critical Illness: Pathophysiologic Mechanisms-Biomarkers-Interventions, and Future Perspectives.
Publication TypeJournal Article
Year of Publication2017
AuthorsPavlakou, P., Liakopoulos V., Eleftheriadis T., Mitsis M., & Dounousi E.
JournalOxid Med Cell Longev
Volume2017
Pagination6193694
Date Published2017
ISSN1942-0994
Λέξεις κλειδιάAcute Kidney Injury, Biomarkers, Critical Illness, Female, Humans, Male, Oxidative Stress
Abstract

Acute kidney injury (AKI) is a multifactorial entity that occurs in a variety of clinical settings. Although AKI is not a usual reason for intensive care unit (ICU) admission, it often complicates critically ill patients' clinical course requiring renal replacement therapy progressing sometimes to end-stage renal disease and increasing mortality. The causes of AKI in the group of ICU patients are further complicated from damaged metabolic state, systemic inflammation, sepsis, and hemodynamic dysregulations, leading to an imbalance that generates oxidative stress response. Abundant experimental and to a less extent clinical data support the important role of oxidative stress-related mechanisms in the injury phase of AKI. The purpose of this article is to present the main pathophysiologic mechanisms of AKI in ICU patients focusing on the different aspects of oxidative stress generation, the available evidence of interventional measures for AKI prevention, biomarkers used in a clinical setting, and future perspectives in oxidative stress regulation.

DOI10.1155/2017/6193694
Alternate JournalOxid Med Cell Longev
PubMed ID29104728
PubMed Central IDPMC5637835

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