Pathogenic BRCA1 mutations may be necessary but not sufficient for tissue genomic heterogeneity: Deep sequencing data from ovarian cancer patients.
Τίτλος | Pathogenic BRCA1 mutations may be necessary but not sufficient for tissue genomic heterogeneity: Deep sequencing data from ovarian cancer patients. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Kotoula, V., Lakis S., Tikas I., Giannoulatou E., Lazaridis G., Papadopoulou K., Manoussou K., Efstratiou I., Papanikolaou A., Fostira F., Vlachos I., Tarlatzis B., & Fountzilas G. |
Journal | Gynecol Oncol |
Volume | 152 |
Issue | 2 |
Pagination | 375-386 |
Date Published | 2019 02 |
ISSN | 1095-6859 |
Λέξεις κλειδιά | Adult, Aged, Aged, 80 and over, BRCA1 Protein, Carcinoma, Ovarian Epithelial, Female, Genotype, Germ-Line Mutation, High-Throughput Nucleotide Sequencing, Humans, Loss of Heterozygosity, Middle Aged, Neoplasm Staging, Retrospective Studies |
Abstract | BACKGROUND: Tissue genomic heterogeneity (t-HET) in patients with epithelial ovarian cancer (OVCA) is related to tissue plasticity, i.e., flexibility to adapt to adverse molecular environments. Here, we interrogated the presence and clinical relevance of OVCA t-HET. |
DOI | 10.1016/j.ygyno.2018.11.016 |
Alternate Journal | Gynecol. Oncol. |
PubMed ID | 30446274 |