A patient with chronic hepatitis B and regression of fibrosis during treatment.
Τίτλος | A patient with chronic hepatitis B and regression of fibrosis during treatment. |
Publication Type | Journal Article |
Year of Publication | 2010 |
Authors | Chang, C. Y., Martin P., Fotiadu A., & Hytiroglou P. |
Journal | Semin Liver Dis |
Volume | 30 |
Issue | 3 |
Pagination | 296-301 |
Date Published | 2010 Aug |
ISSN | 1098-8971 |
Λέξεις κλειδιά | Antiviral Agents, Biopsy, DNA, Viral, Drug Administration Schedule, Hepatitis B Antibodies, Hepatitis B Surface Antigens, Hepatitis B virus, Hepatitis B, Chronic, Humans, Liver Cirrhosis, Male, Middle Aged, Time Factors, Treatment Outcome, Viral Load |
Abstract | We present a patient with HBeAg-negative chronic hepatitis B, in whom significant regression of hepatic fibrosis was achieved after a lengthy antiviral treatment. A liver biopsy specimen obtained at initiation of treatment showed chronic hepatitis B with mild activity (histologic activity index: 7) and marked fibrosis (stage 4, in a scale of 0 to 6). A second biopsy specimen, obtained 10 years later, demonstrated almost complete resolution of necroinflammatory activity and fibrosis. One year after the second biopsy, seroconversion from HBsAg positive to anti-HBs positive status was achieved, and antiviral treatment was discontinued. This case is illustrative of the significant histologic improvement that can be accomplished in chronic hepatitis B when viral activity is suppressed long term. Lengthy antiviral treatment can achieve resorption of excess fibrous tissue, even in patients with marked fibrosis. |
DOI | 10.1055/s-0030-1262515 |
Alternate Journal | Semin. Liver Dis. |
PubMed ID | 20665381 |