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Perfusion parameters analysis of the vertebral bone marrow in patients with Ph¹⁻ chronic myeloproliferative neoplasms (Ph(neg) MPN): a dynamic contrast-enhanced MRI (DCE-MRI) study.

ΤίτλοςPerfusion parameters analysis of the vertebral bone marrow in patients with Ph¹⁻ chronic myeloproliferative neoplasms (Ph(neg) MPN): a dynamic contrast-enhanced MRI (DCE-MRI) study.
Publication TypeJournal Article
Year of Publication2012
AuthorsCourcoutsakis, N., Spanoudaki A., Maris T. G., Astrinakis E., Spanoudakis E., Tsatalas C., & Prassopoulos P.
JournalJ Magn Reson Imaging
Volume35
Issue3
Pagination696-702
Date Published2012 Mar
ISSN1522-2586
Λέξεις κλειδιάAdult, Aged, Aged, 80 and over, Analysis of Variance, Bone Marrow, Bone Marrow Neoplasms, Case-Control Studies, Contrast Media, Female, Humans, Lumbosacral Region, Magnetic Resonance Imaging, Male, Microcirculation, Middle Aged, Neovascularization, Pathologic, Organometallic Compounds, Polycythemia Vera, Predictive Value of Tests, Primary Myelofibrosis, ROC Curve, Sensitivity and Specificity
Abstract

PURPOSE: To evaluate perfusion parameters of the vertebral bone marrow in patients with Philadelphia negative chronic myeloproliferative neoplasms (Ph(neg) MPN) using dynamic contrast-enhanced MRI (DCE-MRI).
MATERIALS AND METHODS: The study enrolled 24 patients with Ph(neg) MPN: 12 patients with myelofibrosis (Group A), 6 with essential thrombocythemia (ET), and 6 with polycythemia vera (PV) (Group B) who underwent DCE-MRI of the lumbosacral spine. Twelve normal individuals served as control group (Group C). Wash-in (WIN), wash-out (WOUT), maximum contrast-enhancement (CE  max), time-to-peak (TTPK), time-to-maximum slope (TMSP), and the WIN/TMSP ratio (WTSP) were calculated.
RESULTS: WIN, CE(max) , and WTSP parameters were higher in Group A than in Group C (P < 0.05). These parameters were significant (P < 0.0001) in discriminating patients with myelofibrosis from normal individuals with sensitivities 74.14%, 87.93%, 74.14%, and specificities 91.07%, 83.93%, 91.07%, respectively. WIN, WOUT, CE(max) , and WTSP parameters were higher in Group A than in Group B (P < 0.05). Group B exhibited no differences in perfusion parameters as compared with Group C with the exception of WOUT.
CONCLUSION: Patients with myelofibrosis exhibited increased perfusion parameters in vertebral bone marrow, which could be consisted with increased vascularity, probably related to neoangiogenesis as opposed to ET or PV patients showing no increased perfusion. DCE-MRI may be of value in discriminating subgroups of Ph(neg) MPN patients and in indicating those progressing to myelofibrosis.

DOI10.1002/jmri.22870
Alternate JournalJ Magn Reson Imaging
PubMed ID22069235

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