Δημοσίευση

Plasma plasminogen activator inhibitor-1 levels in the different phenotypes of the polycystic ovary syndrome.

ΤίτλοςPlasma plasminogen activator inhibitor-1 levels in the different phenotypes of the polycystic ovary syndrome.
Publication TypeJournal Article
Year of Publication2012
AuthorsKoiou, E., Tziomalos K., Dinas K., Katsikis I., Kandaraki E. A., Tsourdi E., Mavridis S., & Panidis D.
JournalEndocr J
Volume59
Issue1
Pagination21-9
Date Published2012
ISSN1348-4540
Λέξεις κλειδιάAdiposity, Adult, Anovulation, Biological Markers, Body Mass Index, Cohort Studies, Female, Humans, Hyperandrogenism, Insulin Resistance, Obesity, Overweight, Phenotype, Plasminogen Activator Inhibitor 1, Polycystic Ovary Syndrome, Practice Guidelines as Topic, Young Adult
Abstract

We aimed to evaluate plasma plasminogen activator inhibitor-1 (PAI-1) antigen levels in women with polycystic ovary syndrome (PCOS) and different levels of adiposity and PCOS phenotypes. We studied 199 women with PCOS and 50 age-matched healthy women divided in normal weight (n=100 and n=25, respectively) and overweight/obese (n=99 and n=25, respectively). Normal weight and overweight/obese patients with PCOS were further divided in patients diagnosed according to the 1990 criteria (i.e. with anovulation and hyperandrogenemia; 1990 criteria group) and in patients with the additional phenotypes introduced in 2003 (i.e. with polycystic ovaries and either anovulation or hyperandrogenemia; additional 2003 criteria group). In normal weight subjects, plasma PAI-1 levels did not differ between women with PCOS (regardless of group) and controls, or between the 1990 criteria and the additional 2003 criteria groups of PCOS. In overweight/obese subjects, plasma PAI-1 levels were higher in both the 1990 criteria and the additional 2003 criteria groups of PCOS compared with controls (p<0.001 and p=0.004, respectively), but did not differ between the 1990 criteria and the additional 2003 criteria groups of PCOS. In conclusion, plasma PAI-1 levels are elevated in overweight/obese women with PCOS but not in normal weight women with this syndrome. Plasma PAI-1 levels do not differ between the phenotypes of PCOS.

Alternate JournalEndocr. J.
PubMed ID21996594

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