Δημοσίευση

Potential delay in the diagnosis of vulvar cancer and associated risk factors in women treated in German gynecological practices.

ΤίτλοςPotential delay in the diagnosis of vulvar cancer and associated risk factors in women treated in German gynecological practices.
Publication TypeJournal Article
Year of Publication2018
AuthorsMuigai, J., Jacob L., Dinas K., Kostev K., & Kalder M.
JournalOncotarget
Volume9
Issue9
Pagination8725-8730
Date Published2018 Feb 02
ISSN1949-2553
Abstract

The goal of this study was to estimate a potential delay in the diagnosis of vulvar cancer and identify associated risk factors in women treated in gynecological practices in Germany. The current study sample included 1,652 women from 218 gynecological practices who received an initial diagnosis of vulvar cancer (ICD 10: C51) between January 2000 and December 2015 (index date). After applying several exclusion criteria, 505 non-cancer controls were matched (1:1) to 505 vulvar cancer cases based on age, health insurance status, and index date. The primary outcome was the delay in vulvar cancer diagnosis in women who had received an initial diagnosis of diseases of Bartholin's gland, inflammation of vagina and vulva, or other specified noninflammatory disorders of vulva, including atrophy, hypertrophy, and cyst. A logistic regression model was used to estimate the association between vulvar cancer and pre-defined diagnoses. The mean age was 60.8 years (SD = 15.6 years), and 4.8% of women had private health insurance coverage. Inflammation of vagina and vulva was diagnosed 328 days (SD = 95 days) prior to the detection of vulvar cancer. This delay was 186 days (SD = 196 days) in patients affected by diseases of Bartholin's gland and 300 days (SD = 116 days) in those with other specified noninflammatory disorders of vulva including atrophy, hypertrophy, and cyst. The risk of vulvar cancer was positively associated with inflammation of vagina and vulva (OR = 2.28) and other specified noninflammatory disorders of vulva (OR = 5.39). The mean potential delay of vulvar cancer diagnosis ranged from 186 to 328 days.

DOI10.18632/oncotarget.23848
Alternate JournalOncotarget
PubMed ID29492231
PubMed Central IDPMC5823582

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