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Predictive Value of 99MTC-hynic-toc Scintigraphy in Lung Neuroendocrine Tumor Diagnosis.

ΤίτλοςPredictive Value of 99MTC-hynic-toc Scintigraphy in Lung Neuroendocrine Tumor Diagnosis.
Publication TypeJournal Article
Year of Publication2019
AuthorsBoutsikou, E., Porpodis K., Chatzipavlidou V., Hardavella G., Gerasimou G., Domvri K., Papadopoulos N., Avramidou V., Spyratos D., Kontakiotis T., & Zarogoulidis K.
JournalTechnol Cancer Res Treat
Volume18
Pagination1533033819842586
Date Published2019 01 01
ISSN1533-0338
Λέξεις κλειδιάAged, Biomarkers, Tumor, Disease Progression, Female, Humans, Image Processing, Computer-Assisted, Kaplan-Meier Estimate, Lung Neoplasms, Male, Middle Aged, Neoplasm Staging, Neuroendocrine Tumors, Octreotide, Organotechnetium Compounds, Predictive Value of Tests, Radionuclide Imaging, Treatment Outcome
Abstract

BACKGROUND: Νeuroendocrine tumors of the lungs are rare arising in the thymus and gastro-entero-pancreatic tract and belonging to foregut of neuroendocrine tumors. The aim of the present prospective study was to estimate the potential impact of single-photon emission computed tomography somatostatin receptor scintigraphy using 99mTc-Tektrotyd on diagnosis, treatment response, and prognosis in patients with neuroendocrine tumors of the lungs.
METHODS: Thirty-six patients with neuroendocrine tumors of the lungs were evaluated by using 99mTc-HYNIC-TOC scintigraphy. The scintigraphic results were compared to liver tissue uptake (Krenning score). Likewise, the functional imaging results were compared with biochemical indices including chromogranin A, neuroendocrine-specific enolase, and insulin-like growth factor 1 at the time of diagnosis (baseline) and disease progression.
RESULTS: The number of somatostatin receptors, expressed with Krenning score, did not show any correlation with the survival of patients both at baseline ( P = .08) and at disease progression ( P = .24), and scintigraphy results did not relate significantly to progression-free survival. Comparing the results of 99mTc-HYNIC-TOC scintigraphy according to the response of patients in the initial treatment, a statistically significant negative correlation was observed both in the first and in the second scintigraphy with patients' response ( P = .001 and P < .001, respectively). The concentrations of biochemical markers were in accordance with scintigraphy results in the diagnosis.
CONCLUSION: This study indicates that 99mTc-HYNIC-TOC scintigraphy appears to be a reliable, noninvasive technique for detection of primary neuroendocrine tumors and their locoregional or distant metastases, although it cannot be used as a neuroendocrine tumors of the lungs predictive technique.

DOI10.1177/1533033819842586
Alternate JournalTechnol Cancer Res Treat
PubMed ID31079574
PubMed Central IDPMC6535698

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