Δημοσίευση

Predictors of humoral response to recommended vaccines in HIV-infected adults.

ΤίτλοςPredictors of humoral response to recommended vaccines in HIV-infected adults.
Publication TypeJournal Article
Year of Publication2017
AuthorsTsachouridou, O., Christaki E., Skoura L., Georgiou A., Nanoudis S., Vasdeki D., Ntziovara M-A., Kotoreni G., Forozidou E., Tsoukra P., Germanidis G., & Metallidis S.
JournalComp Immunol Microbiol Infect Dis
Volume54
Pagination27-33
Date Published2017 Oct
ISSN1878-1667
Λέξεις κλειδιάAdolescent, Adult, Aged, Antibody Formation, Antiretroviral Therapy, Highly Active, CD4 Lymphocyte Count, Cross-Sectional Studies, Female, Hepatitis A, Hepatitis A Vaccines, Hepatitis B, Hepatitis B Vaccines, HIV Infections, Humans, Immunity, Humoral, Male, Middle Aged, Pneumococcal Vaccines, Retrospective Studies, Viral Load, Viremia, Young Adult
Abstract

Humoral response to vaccination has been found to be inadequate in individuals infected with the human immunodeficiency virus (HIV). We retrospectively assessed antibody responses to three routinely recommended vaccines, against hepatitis B, hepatitis A and S. pneumoniae, in HIV-infected individuals. Data regarding age at HIV diagnosis, years of infection, sex, nationality, HIV mode of transmission, CD4 cell count, nadir CD4 count, plasma viral load, HIV stage, insurance status, educational level and treatment with Highly Active Antiretroviral Therapy (HAART) were collected. Univariate and multivariate analysis was performed in order to detect factors associated with response to vaccination. 437 patients were assessed for hepatitis B, 627 patients for hepatitis A and 66 patients for S. pneumoniae serologic vaccine responsiveness. Regarding hepatitis B and hepatitis A, education level and insurance status were the only predictors of response. As for S. pneumoniae vaccination HAART and control of viremia were correlated with better response to vaccination.

DOI10.1016/j.cimid.2017.07.006
Alternate JournalComp. Immunol. Microbiol. Infect. Dis.
PubMed ID28915998

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