Δημοσίευση

Prevention of blood-transfusion-induced impairment of anastomotic healing by leucocyte depletion in rats.

ΤίτλοςPrevention of blood-transfusion-induced impairment of anastomotic healing by leucocyte depletion in rats.
Publication TypeJournal Article
Year of Publication2000
AuthorsApostolidis, S. A., Michalopoulos A. A., Hytiroglou P., Papadopoulos B. N., Fachantidis E. P., Basdanis G. A., & Catsohis C. D.
JournalEur J Surg
Volume166
Issue7
Pagination562-7
Date Published2000 Jul
ISSN1102-4151
Λέξεις κλειδιάAnastomosis, Surgical, Animals, Blood Component Transfusion, Immunosuppression, Intestines, Leukocytes, Models, Animal, Postoperative Complications, Rats, Rats, Wistar, Rupture, Surgical Wound Dehiscence, Transfusion Reaction, Wound Healing
Abstract

OBJECTIVE: To find out what effect whole blood and leucocyte-depleted blood transfusions had on the healing process of intestinal anastomoses in rats.
DESIGN: Experimental study.
SETTING: Teaching hospital, Greece.
SUBJECTS: 100 Wistar rats in five groups of 20 each.
INTERVENTIONS: Small and large bowel anastomoses were made and the five groups were given normal saline, homologous whole blood, heterologous whole blood obtained from PVG rats, homologous leucocyte-depleted blood or heterologous leucocytedepleted blood during the operation.
MAIN OUTCOME MEASURES: Bursting pressures of anastomoses on the third and seventh postoperative days and infective complications.
RESULTS: The groups given whole blood transfusions had significantly more anastomotic abscesses than controls (p = 0.003 compared with heterologous, p = 0.05 compared with homologous for the small bowel, and p = 0.007 for the large bowel). The pressure measurements indicated a significant reduction in anastomotic strength in the same groups compared with the control group (p = 0.0001/p = 0.001 on the third postoperative day, and p = 0.00001/p = 0.0004 on the seventh postoperative day for small and large bowel, respectively). There was no reduction in anastomotic strength in the leucocyte-depleted blood groups.
CONCLUSIONS: Transfusion of leucocyte-depleted blood does not seem to impair intestinal anastomotic healing and carries an acceptable incidence of postoperative complications.

DOI10.1080/110241500750008646
Alternate JournalEur J Surg
PubMed ID10965836

Επικοινωνία

Τμήμα Ιατρικής, Πανεπιστημιούπολη ΑΠΘ, T.K. 54124, Θεσσαλονίκη
 

Συνδεθείτε

Το τμήμα Ιατρικής στα κοινωνικά δίκτυα.
Ακολουθήστε μας ή συνδεθείτε μαζί μας.