Prevention of gestational diabetes mellitus in overweight or obese pregnant women: A network meta-analysis.
Τίτλος | Prevention of gestational diabetes mellitus in overweight or obese pregnant women: A network meta-analysis. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Chatzakis, C., Goulis D. G., Mareti E., Eleftheriades M., Zavlanos A., Dinas K., & Sotiriadis A. |
Journal | Diabetes Res Clin Pract |
Volume | 158 |
Pagination | 107924 |
Date Published | 2019 Dec |
ISSN | 1872-8227 |
Λέξεις κλειδιά | Adult, Diabetes, Gestational, Female, Humans, Network Meta-Analysis, Obesity, Overweight, Pregnancy |
Abstract | AIMS: Several interventions have been implemented to prevent the development of gestational diabetes mellitus (GDM) in obese pregnant women, including physical exercise programs, and administration of metformin, vitamin D and probiotics. The aim of this network meta-analysis was to compare the efficiency of these interventions and identify the optimal.MATERIALS: A network meta-analysis of randomized trials was performed comparing the different interventions for the development of GDM in overweight or obese women, either to each other or placebo/no intervention. A search was conducted in four electronic databases and grey literature sources. The primary outcome was the development of GDM; secondary outcomes were other complications of pregnancy.RESULTS: The meta-analysis included 23 studies (4237 participants). None of the interventions was superior compared with placebo/no intervention for the prevention of GDM. Metformin and physical exercise were superior to placebo/no intervention for gestational weight gain (MD -1.21, 95% CI -2.14 to -0.28 and MD -0.96, 95% CI -1.69 to -0.22, respectively). Metformin was superior to placebo/no intervention for caesarean sections and admission to NICU.CONCLUSIONS: Interventions aiming to prevent the development of GDM in overweight/obese women are not effective, when applied during pregnancy. |
DOI | 10.1016/j.diabres.2019.107924 |
Alternate Journal | Diabetes Res Clin Pract |
PubMed ID | 31738997 |