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The probable auto-antigenic role of lipids (anti-ganglioside antibodies) in the pathogenesis of Alzheimer's disease.

ΤίτλοςThe probable auto-antigenic role of lipids (anti-ganglioside antibodies) in the pathogenesis of Alzheimer's disease.
Publication TypeJournal Article
Year of Publication2014
AuthorsKoutsouraki, E., Hatzifilippou E., Michmizos D., Banaki T., Costa V., & Baloyannis S.
JournalJ Alzheimers Dis
Volume42 Suppl 3
PaginationS163-6
Date Published2014
ISSN1875-8908
Λέξεις κλειδιάAged, Aged, 80 and over, Alzheimer Disease, Antibodies, Anti-Idiotypic, Female, Gangliosides, Humans, Male, Middle Aged
Abstract

We examined the sera of 103 demented patients of a mean age of 75 years and 60 age-matched healthy individuals, using ELISA, to investigate the levels of IgM antibodies against GM1, GD1b, and GQ1b gangliosides and their possible correlation with clinical parameters (age, severity, and type of dementia). All the individuals that demonstrated positive titers of anti-ganglioside antibodies were demented patients whereas normal controls showed borderline or negative values. Significant correlation was revealed between IgM anti-GM1 and both the age of the patients and the severity of dementia. Most of the patients with increased IgM anti-GD1b titers suffered from AD.

DOI10.3233/JAD-132633
Alternate JournalJ. Alzheimers Dis.
PubMed ID24898654

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Τμήμα Ιατρικής, Πανεπιστημιούπολη ΑΠΘ, T.K. 54124, Θεσσαλονίκη
 

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