Δημοσίευση

Recurrent complete hydatidiform mole: where we are, is there a safe gestational horizon? Opinion and mini-review.

ΤίτλοςRecurrent complete hydatidiform mole: where we are, is there a safe gestational horizon? Opinion and mini-review.
Publication TypeJournal Article
Year of Publication2018
AuthorsKalogiannidis, I., Kalinderi K., Kalinderis M., Miliaras D., Tarlatzis B., & Athanasiadis A.
JournalJ Assist Reprod Genet
Volume35
Issue6
Pagination967-973
Date Published2018 Jun
ISSN1573-7330
Abstract

Benign hydatidiform mole, complete or partial, is the most common type of gestational trophoblastic disease (GTD) characterised by excessive trophoblastic proliferation and abnormal embryonic development. Although most complete hydatidiform moles (CHMs) are diploid androgenetic, a few cases of CHMs are biparental, characterised by recurrence and familial clustering. In these rare cases, mutations in NLRP7 or KHDC3L genes, associated with maternal imprinting defects, have been implicated. Current data regarding future pregnancy options in hydatidiform moles are discussed and our opinion is presented based on an incidence that took place in our hospital with a woman with consecutive molar pregnancies. In recurrent hydatidiform moles, DNA testing should be performed and when NLRP7 or KHDC3L mutation are detected, oocyte donation should be proposed as an option to maximise woman's chances of having a normal pregnancy.

DOI10.1007/s10815-018-1202-9
Alternate JournalJ. Assist. Reprod. Genet.
PubMed ID29737470
PubMed Central IDPMC6030002

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