Replication study of GWAS risk loci in Greek multiple sclerosis patients.
Τίτλος | Replication study of GWAS risk loci in Greek multiple sclerosis patients. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Hadjigeorgiou, G. M., Kountra P-M., Koutsis G., Tsimourtou V., Siokas V., Dardioti M., Rikos D., Marogianni C., Aloizou A-M., Karadima G., Ralli S., Grigoriadis N., Bogdanos D., Panas M., & Dardiotis E. |
Journal | Neurol Sci |
Volume | 40 |
Issue | 2 |
Pagination | 253-260 |
Date Published | 2019 Feb |
ISSN | 1590-3478 |
Λέξεις κλειδιά | Adult, Aged, Cohort Studies, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Greece, Humans, Male, Meta-Analysis as Topic, Middle Aged, Multiple Sclerosis, Polymorphism, Single Nucleotide, Young Adult |
Abstract | OBJECTIVES: To validate in an ethnically homogeneous Greek multiple sclerosis (MS) cohort, genetic risk factors for the disease, identified through a number of previous multi-ethnic genome-wide association studies (GWAS).METHODS: A total of 1228 MS cases and 1014 controls were recruited in the study, from 3 MS centers in Greece. We genotyped 35 susceptibility SNPs that emerged from previous GWAS or meta-analyses of GWAS. Allele and genotype single locus regression analysis, adjusted for gender and site, was performed. Permutation testing was applied to all analyses.RESULTS: Six polymorphisms reached statistical significance (permutation p value < 0.05). In particular, rs2760524 of LOC105371664, near RGS1 (permutation p value 0.001), rs3129889 of HLA-DRA, near HLA-DRB1 (permutation p value < 1.00e-04), rs1738074 of TAGAP (permutation p value 0.007), rs703842 of METTL1/CYP27B1 (permutation p value 0.008), rs9596270 of DLEU1 (permutation p value < 1.00e-04), and rs17445836 of LincRNA, near IRF8 (permutation p value 0.001) were identified as susceptibility risk factors in our group.CONCLUSION: The current study replicated a number of GWAS susceptibility SNPs, which implies that some similarities between the examined Greek population and the MS genetic architecture of the GWAS populations do exist. |
DOI | 10.1007/s10072-018-3617-6 |
Alternate Journal | Neurol Sci |
PubMed ID | 30361804 |