Δημοσίευση

Resistant pityriasis lichenoides et varioliformis acuta in a 3-year-old boy: successful treatment with methotrexate.

ΤίτλοςResistant pityriasis lichenoides et varioliformis acuta in a 3-year-old boy: successful treatment with methotrexate.
Publication TypeJournal Article
Year of Publication2010
AuthorsLazaridou, E., Fotiadou C., Tsorova C., Trachana M., Trigoni A., Patsatsi A., & Ioannides D.
JournalInt J Dermatol
Volume49
Issue2
Pagination215-7
Date Published2010 Feb
ISSN1365-4632
Λέξεις κλειδιάBiopsy, Needle, Child, Preschool, Dose-Response Relationship, Drug, Drug Administration Schedule, Drug Therapy, Combination, Follow-Up Studies, Humans, Immunohistochemistry, Male, Methotrexate, Pityriasis Lichenoides, Prednisolone, Risk Assessment, Severity of Illness Index, Time Factors, Treatment Outcome
Abstract

Pityriasis lichenoides et varioliformis acuta (PLEVA) represents the acute clinical subtype of pityriasis lichenoides (PL) and its occurrence is relatively common during childhood. Diagnosis and treatment may sometimes pose certain difficulties. We present the recalcitrant case of a 3-year-old boy with an asymptomatic polymorphic eruption consisting of multiple, scattered, 0.5 cm, round to ovoid, erythematous papules covered in places with a fine scale, vesicles and superficial erosions with thick hemorrhagic crusts. The correlation of the clinical features with the lesional histopathology favored the diagnosis of PLEVA. No first-line treatment scheme succeeded in controlling the eruption of new lesions. The only therapeutic approach that eventually managed to cease the disease evolution was the combination of prednisolone and methotrexate.

DOI10.1111/j.1365-4632.2009.04325.x
Alternate JournalInt. J. Dermatol.
PubMed ID20465649

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