Rhino-cerebral zygomycosis resistant to antimycotic treatment: a case report.
Τίτλος | Rhino-cerebral zygomycosis resistant to antimycotic treatment: a case report. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Vyzantiadis, T-A., Kioumi A., Papadakis E., Braimi M., Dermitzakis E., Tsitouridis I., & Antoniadis A. |
Journal | Mycoses |
Volume | 52 |
Issue | 1 |
Pagination | 87-90 |
Date Published | 2009 Jan |
ISSN | 1439-0507 |
Λέξεις κλειδιά | Aged, Amphotericin B, Anti-Inflammatory Agents, Antifungal Agents, Central Nervous System Diseases, Drug Resistance, Fungal, Fatal Outcome, Humans, Male, Methylprednisolone, Purpura, Thrombocytopenic, Idiopathic, Pyrimidines, Rhinitis, Rhizopus, Triazoles, Voriconazole, Zygomycosis |
Abstract | We report a fatal case of a rhino-cerebral zygomycosis, caused by Rhizopus arrhizus (oryzae). The patient was suffering from idiopathic thrombopenic purpura, diagnosed 1 year earlier. He was already treated with methylprednisolone 5 months prior to his admission to the hospital for a loss of vision and pain in the left eye as well as left orbital cellulitis. After an initial empirical treatment with broad spectrum antibiotics and voriconazole (infection of unknown origin), the patient was treated with liposomal amphotericin as soon as a positive fungal culture revealed a zygomycete. Unfortunately, the mould was resistant to amphotericin B (MIC: 16 microg ml(-1)) and probably to posaconazole (MIC: 4 microg ml(-1)), which was co-administrated a few days later. |
DOI | 10.1111/j.1439-0507.2008.01536.x |
Alternate Journal | Mycoses |
PubMed ID | 18498302 |