Δημοσίευση

The role of reelin gene polymorphisms in the pathogenesis of Alzheimer's disease in a Greek population.

ΤίτλοςThe role of reelin gene polymorphisms in the pathogenesis of Alzheimer's disease in a Greek population.
Publication TypeJournal Article
Year of Publication2011
AuthorsAntoniades, D., Katopodi T., Pappa S., Lampropoulos A., Konsta V., Frydas E., Mpalogiannis S., & Hatzistilianou M.
JournalJ Biol Regul Homeost Agents
Volume25
Issue3
Pagination351-8
Date Published2011 Jul-Sep
ISSN0393-974X
Λέξεις κλειδιάAged, Aged, 80 and over, Alzheimer Disease, Cell Adhesion Molecules, Neuronal, Exons, Extracellular Matrix Proteins, Female, Genetic Markers, Greece, Haplotypes, Humans, Introns, Male, Nerve Tissue Proteins, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Serine Endopeptidases
Abstract

Reelin is an extracellular signaling glycoprotein, which plays a significant role in cytoarchitectonic pattern formation of different brain areas during development. Reelin gene is located on chromosome 7q22. The aim of this study is to investigate the possible association of the following reelin polymorphisms SNP Intron12A/C (rs727531), SNP Exon15A/G (rs2072403), SNP Intron15G/T (rs2072402), SNP Exon22c/g (rs362691), SNP Intron41G/T (rs362719) and SNP Intron59C/T (rs736707) in the pathogenesis of Alzheimer 's disease and the frequency of these polymorphisms in the population of Northern Greece. The study included two groups, A and B. Group A consisted of 50 patients with Alzheimer 's disease and group B of 70 healthy controls. Genomic DNA isolated from blood was used for PCR and subsequent RFLP analysis. According to our results, the exon 22 C/G marker of Reelin is significantly associated with Alzheimer 's disease in the Greek population but the Likelihood Ratio Test shows that the GT haplotype ++ this polymorphism does not affect the phenotype of group A in relation to Group B. This is the first report on a Greek population-based approach.

Alternate JournalJ. Biol. Regul. Homeost. Agents
PubMed ID22023759

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