Δημοσίευση

Serum high-sensitivity C-reactive protein and homocysteine changes during hormonal therapy in women with polycystic ovary syndrome: a prospective, matched study.

ΤίτλοςSerum high-sensitivity C-reactive protein and homocysteine changes during hormonal therapy in women with polycystic ovary syndrome: a prospective, matched study.
Publication TypeJournal Article
Year of Publication2010
AuthorsMakedos, A., Goulis D. G., Papanikolaou A., & Panidis D.
JournalAngiology
Volume61
Issue6
Pagination595-601
Date Published2010 Aug
ISSN1940-1574
Λέξεις κλειδιάAdolescent, Adult, Body Mass Index, C-Reactive Protein, Cyproterone Acetate, Desogestrel, Drug Therapy, Combination, Estrogens, Conjugated (USP), Ethinyl Estradiol, Female, Homocysteine, Humans, Linear Models, Phenotype, Polycystic Ovary Syndrome, Prospective Studies, Statistics, Nonparametric
Abstract

The study evaluated the effect of 5 hormonal regimes on serum levels of high-sensitivity C-reactive protein (hsCRP) and homocysteine (Hcy) in women with polycystic ovary syndrome (PCOS). Women with PCOS received (1) conjugated estrogens and cyproterone acetate (n = 22), (2) 17beta-estradiol and cyproterone acetate (n = 17), (3) ethinyl-estradiol and cyproterone acetate (high dose; n = 20), (4) ethinyl-estradiol plus cyproterone acetate (low dose; n = 12), or (5) ethinyl-estradiol plus desogetrel (n = 12). Both hsCRP and Hcy levels were measured at baseline and after 4, 7, and 12 months. The 17beta-estradiol/cyproterone acetate regime resulted in significant reduction of both hsCRP and Hcy levels (P < .001). The other 4 regimes only resulted in a reduction of Hcy levels (P < .001). In conclusion, the 17beta-estradiol/cyproterone acetate regime had the most favorable effects in women with PCOS regarding serum levels of hsCRP and Hcy.

DOI10.1177/0003319709361198
Alternate JournalAngiology
PubMed ID20395229

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