Δημοσίευση

Serum relaxin and cervical length for the prediction of spontaneous preterm birth in second-trimester symptomatic women.

ΤίτλοςSerum relaxin and cervical length for the prediction of spontaneous preterm birth in second-trimester symptomatic women.
Publication TypeJournal Article
Year of Publication2017
AuthorsPantelis, A., Sotiriadis A., Chatzistamatiou K., Pratilas G., & Dinas K.
JournalUltrasound Obstet Gynecol
Date Published2017 Dec 05
ISSN1469-0705
Abstract

OBJECTIVE: to investigate whether serum relaxin is associated with preterm birth in symptomatic women, either as a standalone test or in the context of a combined model.METHODS: This was a case-control study of women with singleton pregnancy, who presented between 24+0 and 26+6 weeks with threatened preterm labor and intact membranes. Cervical length, full blood count, C-reactive protein and maternal demographics were recorded at presentation. Blood samples were taken for relaxin and these parameters were compared between women who delivered <37 weeks (N=46) and women delivering at term (N=66). Logistic regression with receiver operating characteristic (ROC) curve analysis was used to test for significant predictors for birth <37 and <34 weeks.RESULTS: Women delivering <37 weeks (n=46) had higher mean serum relaxin levels and lower mean cervical length than those delivering at term (p<0.0001). Relaxin alone had 63% (95% CI 49-75) sensitivity for birth <37 weeks and 61% (95%CI 47-74) for birth <34 weeks, at 10% false positive rate. Serum relaxin levels did not correlate with cervical length; a combined model of the two had 0.895 (95%CI 0.835-0.954) area under the curve for birth before 37 weeks, and 0.869 (0.802-0.937) for birth <34 weeks (n=44). Serum relaxin >1010 pg/mL had approximately 58% sensitivity for preterm birth in women with cervical length >15 mm or 25 mm, for 10% false-positive rate.CONCLUSIONS: High serum relaxin levels are associated with increased risk of preterm birth in second-trimester symptomatic women with intact membranes. The combination with cervical length increases predictive accuracy.

DOI10.1002/uog.18972
Alternate JournalUltrasound Obstet Gynecol
PubMed ID29205573

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