The Simons Genome Diversity Project: 300 genomes from 142 diverse populations.
Τίτλος | The Simons Genome Diversity Project: 300 genomes from 142 diverse populations. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Mallick, S., Li H., Lipson M., Mathieson I., Gymrek M., Racimo F., Zhao M., Chennagiri N., Nordenfelt S., Tandon A., Skoglund P., Lazaridis I., Sankararaman S., Fu Q., Rohland N., Renaud G., Erlich, iv Y., Willems T., Gallo C., Spence J. P., Song Y. S., Poletti G., Balloux F., van Driem G., de Knijff P., Romero I. Gallego, Jha A. R., Behar D. M., Bravi C. M., Capelli C., Hervig T., Moreno-Estrada A., Posukh O. L., Balanovska E., Balanovsky O., Karachanak-Yankova S., Sahakyan H., Toncheva D., Yepiskoposyan L., Tyler-Smith C., Xue Y., M Abdullah S., Ruiz-Linares A., Beall C. M., Di Rienzo A., Jeong C., Starikovskaya E. B., Metspalu E., Parik J., Villems R., Henn B. M., Hodoglugil U., Mahley R., Sajantila A., Stamatoyannopoulos G., Wee J. T. S., Khusainova R., Khusnutdinova E., Litvinov S., Ayodo G., Comas D., Hammer M. F., Kivisild T., Klitz W., Winkler C. A., Labuda D., Bamshad M., Jorde L. B., Tishkoff S. A., W Watkins S., Metspalu M., Dryomov S., Sukernik R., Singh L., Thangaraj K., Pääbo S., Kelso J., Patterson N., & Reich D. |
Journal | Nature |
Volume | 538 |
Issue | 7624 |
Pagination | 201-206 |
Date Published | 2016 Oct 13 |
ISSN | 1476-4687 |
Λέξεις κλειδιά | African Continental Ancestry Group, Animals, Australia, Continental Population Groups, Datasets as Topic, Genetic Variation, Genetics, Population, Genome, Human, Genomics, History, Ancient, Human Migration, Humans, Mutation Rate, Neanderthals, New Guinea, Oceanic Ancestry Group, Phylogeny, Sequence Analysis, DNA, Species Specificity, Time Factors |
Abstract | Here we report the Simons Genome Diversity Project data set: high quality genomes from 300 individuals from 142 diverse populations. These genomes include at least 5.8 million base pairs that are not present in the human reference genome. Our analysis reveals key features of the landscape of human genome variation, including that the rate of accumulation of mutations has accelerated by about 5% in non-Africans compared to Africans since divergence. We show that the ancestors of some pairs of present-day human populations were substantially separated by 100,000 years ago, well before the archaeologically attested onset of behavioural modernity. We also demonstrate that indigenous Australians, New Guineans and Andamanese do not derive substantial ancestry from an early dispersal of modern humans; instead, their modern human ancestry is consistent with coming from the same source as that of other non-Africans. |
DOI | 10.1038/nature18964 |
Alternate Journal | Nature |
PubMed ID | 27654912 |
PubMed Central ID | PMC5161557 |
Grant List | R01 GM100233 / GM / NIGMS NIH HHS / United States R01 HG006399 / HG / NHGRI NIH HHS / United States R01 GM059290 / GM / NIGMS NIH HHS / United States R00 GM111744 / GM / NIGMS NIH HHS / United States R01 GM094402 / GM / NIGMS NIH HHS / United States UL1 TR001067 / TR / NCATS NIH HHS / United States |