Surfactant Protein A and B Gene Polymorphisms and Risk of Respiratory Distress Syndrome in Late-Preterm Neonates.
| Τίτλος | Surfactant Protein A and B Gene Polymorphisms and Risk of Respiratory Distress Syndrome in Late-Preterm Neonates. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Tsitoura, M-E. I., Stavrou E. F., Maraziotis I. A., Sarafidis K., Athanassiadou A., & Dimitriou G. |
| Journal | PLoS One |
| Volume | 11 |
| Issue | 11 |
| Pagination | e0166516 |
| Date Published | 2016 |
| ISSN | 1932-6203 |
| Λέξεις κλειδιά | Adrenal Cortex Hormones, Alleles, Birth Weight, Cross-Sectional Studies, Female, Gene Expression, Genetic Predisposition to Disease, Gestational Age, Haplotypes, Heterozygote, Humans, Infant, Newborn, Infant, Premature, Male, Polymorphism, Single Nucleotide, Pregnancy, Prospective Studies, Pulmonary Surfactant-Associated Protein A, Pulmonary Surfactant-Associated Protein B, Respiratory Distress Syndrome, Newborn, Risk Factors, Sex Factors |
| Abstract | BACKGROUND AND OBJECTIVES: Newborns delivered late-preterm (between 340/7 and 366/7 weeks of gestation) are at increased risk of respiratory distress syndrome (RDS). Polymorphisms within the surfactant protein (SP) A and B gene have been shown to predispose to RDS in preterm neonates. The aim of this study was to investigate whether specific SP-A and/or SP-B genetic variants are also associated with RDS in infants born late-preterm.METHODS: This prospective cross-sectional study included 56 late-preterm infants with and 60 without RDS. Specific SP-A1/SP-A2 haplotypes and SP-B Ile131Thr polymorphic alleles were determined in blood specimens using polymerase-chain-reaction and DNA sequencing.RESULTS: The SP-A1 6A4 and the SP-A2 1A5 haplotypes were significantly overrepresented in newborns with RDS compared to controls (OR 2.86, 95%CI 1.20-6.83 and OR 4.68, 95%CI 1.28-17.1, respectively). The distribution of the SP-B Ile131Thr genotypes was similar between the two late-preterm groups. Overall, the SP-A1 6A4 or/and SP-A2 1A5 haplotype was present in 20 newborns with RDS (35.7%), resulting in a 4.2-fold (1.60-11.0) higher probability of RDS in carriers. Multivariable regression analysis revealed that the effect of SP-A1 6A4 and SP-A2 1A5 haplotypes was preserved when adjusting for known risk or protective factors, such as male gender, smaller gestational age, smaller weight, complications of pregnancy, and administration of antenatal corticosteroids.CONCLUSIONS: Specific SP-A genetic variants may influence the susceptibility to RDS in late-preterm infants, independently of the effect of other perinatal factors. |
| DOI | 10.1371/journal.pone.0166516 |
| Alternate Journal | PLoS ONE |
| PubMed ID | 27835691 |
| PubMed Central ID | PMC5106092 |
