A Time Course of Bevacizumab (Anti-VEGF) Effect on Rat Peritoneum: Relations Between Antiadhesive Action and Fibrin Regulation Enzymes.
Τίτλος | A Time Course of Bevacizumab (Anti-VEGF) Effect on Rat Peritoneum: Relations Between Antiadhesive Action and Fibrin Regulation Enzymes. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Micha, A-E., Psarras K., Ouroumidis O., Siska E., Vlachaki E., Lymperopoulos A., Symeonidis N., Nikolaidou C., Venizelos I., Koliakos G., & Pavlidis T. E. |
Journal | Surg Innov |
Volume | 24 |
Issue | 6 |
Pagination | 543-551 |
Date Published | 2017 Dec |
ISSN | 1553-3514 |
Λέξεις κλειδιά | Angiogenesis Inhibitors, Animals, Bevacizumab, Cecum, Fibrinolysis, Male, Matrix Metalloproteinase 9, Peritoneum, Plasminogen Activator Inhibitor 1, Rats, Rats, Wistar, Tissue Adhesions, Tissue Plasminogen Activator |
Abstract | BACKGROUND: To investigate the early and late antiadhesive effect and any changes of fibrin matrix regulation enzymes on rat peritoneum, after local administration of bevacizumab.METHODS: Rats were subjected to cecal abrasion. Bevacizumab (5 mg/kg) against placebo was given intraperitoneally. On the 2nd, 14th, and 28th postoperative days adhesions were scored, and tissue plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1), matrix metalloproteinase-9 (MMP-9), degree of fibrosis, and angiogenesis were measured in abrased cecum and in intact parietal peritoneum.RESULTS: Bevacizumab significantly reduced adhesions up to 15% on the 2nd, 52.5% on the 14th, and 55% on the 28th postoperative day, and significantly increased tPA concentrations in peritoneum. PAI-1 was decreased, and a significantly higher tPA/PAI-1 ratio along with an increase of MMP-9 was measured at all time points. Fibrosis and angiogenesis were significantly lower on the 14th and 28th postoperative days.CONCLUSIONS: Local bevacizumab administration has a strong early and late antiadhesive action on rat peritoneum, mediated by changes in the tPA/PAI-1 and MMP balance in favor of fibrinolysis up to 28 days after operations. |
DOI | 10.1177/1553350617729510 |
Alternate Journal | Surg Innov |
PubMed ID | 28877644 |