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Tumor Mutational Patterns and Infiltrating Lymphocyte Density in Young and Elderly Patients With Breast Cancer.

ΤίτλοςTumor Mutational Patterns and Infiltrating Lymphocyte Density in Young and Elderly Patients With Breast Cancer.
Publication TypeJournal Article
Year of Publication2020
AuthorsNikolaidi, A., Kotoula V., Koliou G-A., Giannoulatou E., Papadopoulou K., Zagouri F., Pentheroudakis G., Gogas H., Bobos M., Chatzopoulos K., Oikonomopoulos G., Pectasides D., Saloustros E., Arnogiannaki N., Nicolaou I., Papakostas P., Bompolaki I., Aravantinos G., Athanasiadis I., & Fountzilas G.
JournalCancer Genomics Proteomics
Volume17
Issue2
Pagination181-193
Date Published2020 Mar-Apr
ISSN1790-6245
Abstract

BACKGROUND/AIM: Age may pertain to different tumor genotype characteristics which may interfere with treatment efficacy and prognosis. We investigated the distribution and prognostic effect of mutations and tumor infiltrating lymphocyte (stromal TIL density) in young (≤35 years) and elderly (>65 years) early breast cancer patients.
MATERIALS AND METHODS: Paraffin tumor genotypes of all clinical subtypes from 345 patients were examined.
RESULTS: A total of 638 mutations were detected in 221 patients (64.1%). Compared to young, elderly patients presented with lower TIL density (p<0.001) but more TILs in TP53 mutated tumors (p=0.042). Mutation in one, rather than in 2 or more genes, conferred better outcome (DFS: HR=0.51, p=0.016; OS: HR=0.47, p=0.015) but the effect was age-independent.
CONCLUSION: There are fewer TILs and different mutations patterns in tumors from elderly patients compared to young. Age and TIL-independent gene agnostic co-mutations affect patient outcome.

DOI10.21873/cgp.20179
Alternate JournalCancer Genomics Proteomics
PubMed ID32108041
PubMed Central IDPMC7078837

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Τμήμα Ιατρικής, Πανεπιστημιούπολη ΑΠΘ, T.K. 54124, Θεσσαλονίκη
 

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