Tumor Protein p53 (TP53) Gene and Left Main Coronary Artery Disease.
Τίτλος | Tumor Protein p53 (TP53) Gene and Left Main Coronary Artery Disease. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Kolovou, V., Tsipis A., Mihas C., Katsiki N., Vartela V., Koutelou M., Manolopoulou D., Leondiadis E., Iakovou I., Mavrogieni S., & Kolovou G. |
Journal | Angiology |
Volume | 69 |
Issue | 8 |
Pagination | 730-735 |
Date Published | 2018 Sep |
ISSN | 1940-1574 |
Abstract | Patients with left main (LM) coronary artery disease (CAD) are at the highest risk of cardiovascular events. We evaluated possible gene polymorphisms of tumor protein 53 ( TP53, rs1042522, p.Arg72Pro) that can differentiate LM-CAD from patients with more peripheral CAD (MP-CAD) and healthy participants (control group) in 520 individuals (LM-CAD, n = 175; MP-CAD, n = 185; and control group, n = 160). Patients with LM-CAD had the lowest Arg/Arg genotype frequency (36.0%) compared with the MP-CAD (57.3%) and control groups (61.9%), P < .001 for both comparisons. Similarly, the Arg allele was more frequent in the control group than in patients with MP-CAD (78.8% vs 73.2%; P = .007) and LM-CAD (78.8% vs 64.0%; P < .001). The Arg/Pro genotype was more frequent in the LM-CAD group compared with the MP-CAD and control groups (56.0, 31.9, and 33.8, respectively, P < .001 for both comparisons). Furthermore, the frequency of Arg/Arg genotypes was the lowest in the LM-CAD group compared with the MP-CAD and control groups. Knowing that TP53 is an antioncogene protein that acts as a tumor suppressor and regulator of apoptosis, the lowest frequency of Arg/Arg genotype observed in these high-risk patients may indicate lower protection from the atherosclerosis process. Replication studies are needed to evaluate this association. |
DOI | 10.1177/0003319718760075 |
Alternate Journal | Angiology |
PubMed ID | 29482350 |