Δημοσίευση

Twenty-four hour efficacy with the dorzolamide/timolol-fixed combination compared with the brimonidine/timolol-fixed combination in primary open-angle glaucoma.

ΤίτλοςTwenty-four hour efficacy with the dorzolamide/timolol-fixed combination compared with the brimonidine/timolol-fixed combination in primary open-angle glaucoma.
Publication TypeJournal Article
Year of Publication2012
AuthorsKonstas, A. G. P., Quaranta L., Yan D. B., Mikropoulos D. G., Riva I., Gill N. K., Barton K., & Haidich A-B.
JournalEye (Lond)
Volume26
Issue1
Pagination80-7
Date Published2012 Jan
ISSN1476-5454
Λέξεις κλειδιάAged, Antihypertensive Agents, Cross-Over Studies, Drug Combinations, Female, Glaucoma, Open-Angle, Humans, Intraocular Pressure, Male, Medication Adherence, Prospective Studies, Quinoxalines, Sulfonamides, Thiophenes, Time Factors, Timolol, Treatment Outcome
Abstract

AIM: The aim of this study is to compare the 24-hour efficacy of dorzolamide/timolol-fixed combination (DTFC) and brimonidine/timolol-fixed combination (BTFC) in primary open-angle glaucoma (POAG).METHODS: One eye each of 77 POAG patients was included in this prospective, observer-masked, crossover comparison. Following a 2-month timolol run-in period, patients had three intraocular pressure (IOP) measurements at 1000, 1200 and 1400 h while on timolol treatment. Patients showing at least a 20% IOP reduction on timolol were randomised to 3 months of therapy with DTFC or BTFC, and then were crossed over to the opposite therapy.RESULTS: Sixty POAG patients completed the study. The mean 24-hour IOP was significantly reduced with both the fixed combinations compared with the timolol-treated diurnal IOP (P < 0.001). When the two fixed combinations were compared directly, DTFC demonstrated a lower mean 24-hour IOP level as compared with BTFC (mean difference: -0.7 mm Hg, 95% confidence interval (CI): (-1.0, -0.3), P < 0.001). At two individual time points, DTFC significantly reduced IOP more than BTFC: at 1800 h (-1.0 mm Hg, 95% CI (-1.6,-0.5), P = 0.001) and at 0200 (-0.9 mm Hg, 95% CI: (-1.4,-0.5), P = 0.001). No significant difference existed for the other time points.CONCLUSION: Both the fixed combinations significantly reduce 24-hour IOP in POAG. DTFC provided significantly better 24-hour efficacy.

DOI10.1038/eye.2011.239
Alternate JournalEye (Lond)
PubMed ID21960068
PubMed Central IDPMC3259580

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