Twenty-four hour efficacy with the dorzolamide/timolol-fixed combination compared with the brimonidine/timolol-fixed combination in primary open-angle glaucoma.
Τίτλος | Twenty-four hour efficacy with the dorzolamide/timolol-fixed combination compared with the brimonidine/timolol-fixed combination in primary open-angle glaucoma. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Konstas, A. G. P., Quaranta L., Yan D. B., Mikropoulos D. G., Riva I., Gill N. K., Barton K., & Haidich A-B. |
Journal | Eye (Lond) |
Volume | 26 |
Issue | 1 |
Pagination | 80-7 |
Date Published | 2012 Jan |
ISSN | 1476-5454 |
Λέξεις κλειδιά | Aged, Antihypertensive Agents, Cross-Over Studies, Drug Combinations, Female, Glaucoma, Open-Angle, Humans, Intraocular Pressure, Male, Medication Adherence, Prospective Studies, Quinoxalines, Sulfonamides, Thiophenes, Time Factors, Timolol, Treatment Outcome |
Abstract | AIM: The aim of this study is to compare the 24-hour efficacy of dorzolamide/timolol-fixed combination (DTFC) and brimonidine/timolol-fixed combination (BTFC) in primary open-angle glaucoma (POAG).METHODS: One eye each of 77 POAG patients was included in this prospective, observer-masked, crossover comparison. Following a 2-month timolol run-in period, patients had three intraocular pressure (IOP) measurements at 1000, 1200 and 1400 h while on timolol treatment. Patients showing at least a 20% IOP reduction on timolol were randomised to 3 months of therapy with DTFC or BTFC, and then were crossed over to the opposite therapy.RESULTS: Sixty POAG patients completed the study. The mean 24-hour IOP was significantly reduced with both the fixed combinations compared with the timolol-treated diurnal IOP (P < 0.001). When the two fixed combinations were compared directly, DTFC demonstrated a lower mean 24-hour IOP level as compared with BTFC (mean difference: -0.7 mm Hg, 95% confidence interval (CI): (-1.0, -0.3), P < 0.001). At two individual time points, DTFC significantly reduced IOP more than BTFC: at 1800 h (-1.0 mm Hg, 95% CI (-1.6,-0.5), P = 0.001) and at 0200 (-0.9 mm Hg, 95% CI: (-1.4,-0.5), P = 0.001). No significant difference existed for the other time points.CONCLUSION: Both the fixed combinations significantly reduce 24-hour IOP in POAG. DTFC provided significantly better 24-hour efficacy. |
DOI | 10.1038/eye.2011.239 |
Alternate Journal | Eye (Lond) |
PubMed ID | 21960068 |
PubMed Central ID | PMC3259580 |