Δημοσίευση

Twenty-four hour efficacy with preservative free tafluprost compared with latanoprost in patients with primary open angle glaucoma or ocular hypertension.

ΤίτλοςTwenty-four hour efficacy with preservative free tafluprost compared with latanoprost in patients with primary open angle glaucoma or ocular hypertension.
Publication TypeJournal Article
Year of Publication2013
AuthorsKonstas, A. G. P., Quaranta L., Katsanos A., Riva I., Tsai J. C., Giannopoulos T., Voudouragkaki I. C., Paschalinou E., Floriani I., & Haidich A-B.
JournalBr J Ophthalmol
Volume97
Issue12
Pagination1510-5
Date Published2013 Dec
ISSN1468-2079
Λέξεις κλειδιάAged, Antihypertensive Agents, Female, Glaucoma, Open-Angle, Humans, Intraocular Pressure, Male, Middle Aged, Ocular Hypertension, Preservatives, Pharmaceutical, Prospective Studies, Prostaglandins F, Prostaglandins F, Synthetic, Treatment Outcome
Abstract

AIM: To compare 24 h intraocular pressure (IOP) control obtained with preservative free (PF) tafluprost 0.0015% versus branded preservative containing latanoprost 0.005% administered as first choice monotherapy in patients with primary open angle glaucoma (POAG) or ocular hypertension (OHT).METHODS: This prospective, observer-masked, crossover study included consecutive newly diagnosed patients with POAG or OHT, and baseline IOP between 24 and 33 mm Hg. Qualifying patients underwent baseline untreated 24 h IOP monitoring in habitual positions, with Goldmann tonometry at times 10:00, 14:00, 18:00 and 22:00, and Perkins supine tonometry at times 02:00 and 06:00. They were then randomised to either latanoprost or tafluprost, administered in the evening, for 3 months and then switched to the opposite therapy for another 3 months. 24 h monitoring was repeated at the end of each treatment period.RESULTS: 38 patients completed the study. Mean untreated 24 h IOP (24.9 mm Hg) was significantly reduced with both prostaglandins (p<0.001). Tafluprost demonstrated similar mean 24 h efficacy compared with latanoprost (17.8 vs 17.7 mm Hg; p=0.417). Latanoprost demonstrated significantly better 24 h trough IOP (15.9 vs 16.3 mm Hg; p=0.041) whereas tafluprost provided significantly lower 24 h IOP fluctuation (3.2 vs 3.8 mm Hg; p=0.008). No significant difference existed between the two prostaglandins for any adverse event.CONCLUSIONS: PF tafluprost achieved similar 24 h IOP reduction to branded latanoprost. The current study highlights the importance of complete assessment of efficacy over 24 h.CLINICAL TRIALS REGISTRATION: NCT01162603.

DOI10.1136/bjophthalmol-2012-303026
Alternate JournalBr J Ophthalmol
PubMed ID23681371

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