Update on the role of Interleukin 17 in rheumatologic autoimmune diseases.
Τίτλος | Update on the role of Interleukin 17 in rheumatologic autoimmune diseases. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Konya, C., Paz, iv Z., Apostolidis S. A., & Tsokos G. C. |
Journal | Cytokine |
Volume | 75 |
Issue | 2 |
Pagination | 207-15 |
Date Published | 2015 Oct |
ISSN | 1096-0023 |
Abstract | Interleukin 17 is a proinflammatory cytokine produced by CD4+ T cells when in the presence of a distinct set of cytokines and other cells. Preclinical and clinical studies have assigned a role to IL-17 in tissue inflammation and damage in patients with rheumatoid arthritis, psoriasis and psoriatic arthritis, ankylosing spondylitis and systemic lupus erythematosus. Antibodies blocking the action of IL-17 have already been approved to treat patients with psoriasis and it is expected that they may also benefit patients with other rheumatic diseases. |
DOI | 10.1016/j.cyto.2015.01.003 |
Alternate Journal | Cytokine |
PubMed ID | 26028353 |